Biological membranes and membrane proteins, responsible for numerous exciting
biological processes, present one of the paramount challenges in biophysics today …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

The membrane protein complex between the sarcoplasmic reticulum Ca2+-ATPase
(SERCA) and phospholamban (PLN) controls Ca2+ transport in cardiomyocytes, thereby …

► Lipid bicelles have matured to full membership in the club of lipid phases.► Numerous
techniques have elucidated the character traits of bicelles.► Bicelles are exemplary citizens …

The last five years have witnessed major developments in the understanding of the allosteric
phenomenon, broadly defined as coupling between remote molecular sites. Such advances …

Membrane proteins mediate many critical functions in cells. Determining their three-
dimensional structures in the native lipid environment has been one of the main objectives …

In this chapter, we summarize the isotopic labeling strategies used to obtain high-quality
solution and solid-state NMR spectra of biological samples, with emphasis on integral …

Conspectus Membrane proteins mediate a plethora of cellular functions and represent
important targets for drug development. Unlike soluble proteins, membrane proteins require …

Magic angle spinning solid-state NMR (MAS ssNMR) spectroscopy is a powerful method for
atomic-resolution structure determination of biomacromolecules that are recalcitrant to …

The M2 protein of influenza A viruses forms a tetrameric proton channel that is targeted by
the amantadine class of antiviral drugs. A S31N mutation in the transmembrane (TM) …