Bioinspired skeletal reorganization approach for the synthesis of steroid natural products

Y Wang, J Gui - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus Steroids, termed “keys to life” by Rupert Witzmann, have a wide variety of
biological activities, including anti-inflammatory, antishock, immunosuppressive, stress …

Controllable skeletal reorganizations in natural product synthesis

Z Zhang, X Qian, Y Gu, J Gui - Natural Product Reports, 2024 - pubs.rsc.org
Covering: 2016 to 2023The synthetic chemistry community is always in pursuit of efficient
routes to natural products. Among the many available general strategies, skeletal …

Neotricitrinols A–C, unprecedented citrinin trimers with anti-osteoporosis activity from the deep-sea-derived Penicillium citrinum W23

ZH He, CL Xie, T Wu, Y Zhang, ZB Zou, MM Xie… - Bioorganic …, 2023 - Elsevier
Marine fungi are prolific source for the discovery of structurally diverse and bioactive
molecules. In our search for new anti-osteoporosis compounds from deep-sea-derived fungi …

Ferroptosis Inhibitory Compounds from the Deep-Sea-Derived Fungus Penicillium sp. MCCC 3A00126

YJ Hao, ZB Zou, MM Xie, Y Zhang, L Xu, HY Yu, HB Ma… - Marine Drugs, 2023 - mdpi.com
Two new xanthones (1 and 2) were isolated from the deep-sea-derived fungus Penicillium
sp. MCCC 3A00126 along with 34 known compounds (3–36). The structures of the new …

[HTML][HTML] Penicopeptide A (PPA) from the deep-sea-derived fungus promotes osteoblast-mediated bone formation and alleviates ovariectomy-induced bone loss by …

CL Xie, YT Yue, JP Xu, N Li, T Lin, GR Ji… - Pharmacological …, 2023 - Elsevier
The potential of marine natural products as effective drugs for osteoporosis treatment is an
understudied area. In this study, we investigated the ability of lead compounds from deep …

Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities

Y Zhang, CL Xie, Y Wang, XW He, MM Xie, Y Li… - Marine Drugs, 2023 - mdpi.com
Three new polyketides (penidihydrocitrinins A–C, 1–3) and fourteen known compounds (4–
17) were isolated from the deep-sea-derived Penicillium citrinum W17. Their structures were …

Chemical Constituents of the Deep‐sea Gammarid Shrimp‐Derived Fungus Penicillium citrinum XIA‐16

HY Yu, Y Li, M Zhang, ZB Zou, YJ Hao… - Chemistry & …, 2023 - Wiley Online Library
Abstract One new alkaloid,(S)‐2‐acetamido‐4‐(2‐(methylamino) phenyl)‐4‐oxobutanoic
acid (1), was isolated from the deep‐sea‐derived Penicillium citrinum XIA‐16, together with …

Anti-necroptosis and anti-ferroptosis compounds from the Deep-Sea-Derived fungus Aspergillus sp. MCCC 3A00392

HY Yu, YS Chen, Y Wang, ZB Zou, MM Xie, Y Li… - Bioorganic …, 2024 - Elsevier
Abstract Eight undescribed (1–8) and 46 known compounds (9–54) were isolated from the
deep-sea-derived Aspergillus sp. MCCC 3A00392. Compounds 1–3 were three novel …

Hyposterolactone A, a 3α‐Hydroxy Steroidal Lactone from the Deep‐Sea‐Derived Fungus Hypocrea sp. ZEN14

L Xu, HB Ma, T Wu, LF Liu, MM Xie… - Chemistry & …, 2023 - Wiley Online Library
Chemical investigation of the deep‐sea‐derived fungus Hypocrea sp. ZEN14 afforded a
new 3α‐hydroxy steroidal lactone, hyposterolactone A (1) and 25 known secondary …

Genome Mining of a Deep-Sea-Derived Penicillium allii-sativi Revealed Polyketide-Terpenoid Hybrids with Antiosteoporosis Activity

CL Xie, TZ Wu, Y Wang, RJ Capon, R Xu… - Organic …, 2024 - ACS Publications
Two novel meroterpenoids, alliisativins A and B (1, 2) were discovered through a genome-
based exploration of the biosynthetic gene clusters of the deep-sea-derived fungus …