[HTML][HTML] Endothelial protection by sodium-glucose cotransporter 2 inhibitors: a literature review of in vitro and in vivo studies

N Mylonas, PE Nikolaou, P Karakasis… - International Journal of …, 2024 - mdpi.com
Endothelial dysfunction often precedes the development of cardiovascular diseases,
including heart failure. The cardioprotective benefits of sodium-glucose cotransporter 2 …

SGLT2 inhibitors: from glucose-lowering to cardiovascular benefits

A Preda, F Montecucco, F Carbone… - Cardiovascular …, 2024 - academic.oup.com
An increasing number of individuals are at high risk of type 2 diabetes (T2D) and its
cardiovascular complications, including heart failure (HF), chronic kidney disease (CKD) …

Effect of empagliflozin on total myocardial infarction events by type and additional coronary outcomes: insights from the randomized EMPA-REG OUTCOME trial

D Fitchett, B Zinman, SE Inzucchi, C Wanner… - Cardiovascular …, 2024 - Springer
Background The effect of empagliflozin, a sodium-glucose-co-transporter-2 inhibitor, on risk
for myocardial infarction has not been fully characterized. Methods This study comprised …

The role of coronary microcirculation in heart failure with preserved ejection fraction: An unceasing odyssey

K Dimitriadis, P Theofilis, G Koutsopoulos… - Heart Failure …, 2024 - Springer
Heart failure with preserved ejection fraction (HFpEF) represents an entity with complex
pathophysiologic pathways, among which coronary microvascular dysfunction (CMD) is …

Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium–Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor …

G Gallo, M Volpe - International Journal of Molecular Sciences, 2024 - mdpi.com
Different multifactorial pathophysiological processes are involved in the development of
heart failure (HF), including neurohormonal dysfunction, the hypertrophy of cardiomyocytes …

ANOCA updated: From pathophysiology to modern clinical practice

K Dimitriadis, N Pyrpyris, A Sakalidis, E Dri… - Cardiovascular …, 2024 - Elsevier
Lately, a large number of stable ischemic patients, with no obstructed coronary arteries are
being diagnosed. Despite this condition, which is being described as angina with no …

The search for the holy grail: the balance between the risk of thrombosis and bleeding in patients

S Agewall - European Heart Journal-Cardiovascular …, 2024 - academic.oup.com
The balance between bleeding and cardiovascular events by dual antiplatelet treatment
(DAPT) is a critical concern in patients undergoing percutaneous coronary intervention …

Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors, anti-diabetic drugs in heart failure and cognitive impairment: potential …

MA Riemma, E Mele, M Donniacuo… - Frontiers in …, 2024 - frontiersin.org
Heart failure and cognitive impairment emerge as public health problems that need to be
addressed due to the aging global population. The conditions that often coexist are strongly …

Preclinical systolic dysfunction relating to ankle-brachial index among high-risk PAD population with preserved left ventricular ejection fraction

YH Lin, KT Sung, CT Tsai, YH Lai, CI Lo, FC Yu… - Scientific Reports, 2024 - nature.com
Peripheral artery disease (PAD) shares common clinical risk factors, for example,
endothelial dysfunction, with preserved ejection fraction (LVEF) heart failure (HFpEF) …

Connexin43, A Promising Target to Reduce Cardiac Arrhythmia Burden in Pulmonary Arterial Hypertension

M Sykora, B Szeiffova Bacova, K Andelova… - International Journal of …, 2024 - mdpi.com
While essential hypertension (HTN) is very prevalent, pulmonary arterial hypertension (PAH)
is very rare in the general population. However, due to progressive heart failure, prognoses …