Pharmacological management of chronic pelvic pain in women

ET Carey, SR Till, S As-Sanie - Drugs, 2017 - Springer
Chronic pelvic pain (CPP) is a multifaceted condition that often has both peripheral and
central generators of pain. An understanding of neurobiology and neuropsychology of CPP …

[HTML][HTML] Mechanistic insights into the efficacy of memantine in treating certain drug addictions

C Montemitro, A Angebrandt, TY Wang… - Progress in Neuro …, 2021 - Elsevier
The deleterious effects of the drug addiction epidemic are compounded by treatment
strategies that are only marginally efficacious. Memantine is a unique glutamatergic …

[HTML][HTML] An excessive increase in glutamate contributes to glucose-toxicity in β-cells via activation of pancreatic NMDA receptors in rodent diabetes

XT Huang, C Li, XP Peng, J Guo, SJ Yue, W Liu… - Scientific reports, 2017 - nature.com
In the nervous system, excessive activation of NMDA receptors causes neuronal injury.
Although activation of NMDARs has been proposed to contribute to the progress of diabetes …

[HTML][HTML] Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model

P Bøttger, S Glerup, B Gesslein, NB Illarionova… - Scientific Reports, 2016 - nature.com
Migraine is a complex brain disorder, and understanding the complexity of this prevalent
disease could improve quality of life for millions of people. Familial Hemiplegic Migraine …

Regulation of human brain microvascular endothelial cell adhesion and barrier functions by memantine

F Wang, Z Zou, Y Gong, D Yuan, X Chen… - Journal of Molecular …, 2017 - Springer
Vascular risk factors have been linked to cognitive decline and dementia in the elderly.
Microvascular inflammation, especially of the endothelium, may contribute to the …

Memantine and its benefits for cancer, cardiovascular and neurological disorders

V Shafiei-Irannejad, S Abbaszadeh… - European Journal of …, 2021 - Elsevier
Memantine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist that was
initially indicated for the treatment of moderate to severe Alzheimer's disease. It is now also …

[HTML][HTML] Cardiotonic steroids as modulators of neuroinflammation

AM Orellana, PF Kinoshita, JA Leite… - Frontiers in …, 2016 - frontiersin.org
Cardiotonic steroids (CTS) are a class of specific ligands of the Na+, K+-ATPase (NKA). NKA
is a P-type ATPase that is ubiquitously expressed and although well known to be …

Pathophysiology in the comorbidity of Bipolar Disorder and Alzheimer's Disease: pharmacological and stem cell approaches

JC Correa-Velloso, MCB Goncalves, Y Naaldijk… - Progress in Neuro …, 2018 - Elsevier
Neuropsychiatric disorders involve various pathological mechanisms, resulting in
neurodegeneration and brain atrophy. Neurodevelopmental processes have shown to be …

[HTML][HTML] Memantine improves attentional processes in fragile X-associated tremor/ataxia syndrome: electrophysiological evidence from a randomized controlled trial

JC Yang, A Rodriguez, A Royston, YQ Niu, M Avar… - Scientific reports, 2016 - nature.com
Progressive cognitive deficits are common in patients with fragile X-associated tremor/ataxia
syndrome (FXTAS), with no targeted treatment yet established. In this substudy of the first …

Metallomics‐based platforms for comparing the human blood serum profiles between bipolar disorder and schizophrenia patients

G de Souza Pessôa, JR de Jesus… - Rapid …, 2020 - Wiley Online Library
Rationale An evaluation of bipolar disorder (BD) and schizophrenia (SCZ) was carried out,
from a metallomics point of view, using native conditions, attempting to preserve the …