Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause
of dementia among the elderly worldwide. Despite intense efforts to develop drugs for …

One of the primary genetic risk factors for Alzheimer's disease (AD) is the presence of the Ɛ4
allele of apolipoprotein E (APOE). APOE is a polymorphic lipoprotein that is a major …

Oligonucleotide therapies are currently experiencing a resurgence driven by advances in
backbone chemistry and discoveries of novel therapeutic pathways that can be uniquely and …

The most prevalent genetic risk factor for Alzheimer's disease (AD) is Apolipoprotein E
(ApoE), a gene located on chromosome 19 that encodes three alleles (e2, e3, and e4) that …

Alzheimer's disease (AD) represents a particular therapeutic challenge because its
aetiology is very complex, with dynamic progression from preclinical to clinical stages …

Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk.
APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk …

Polyglutamine (polyQ) disorders are a group of nine neurodegenerative diseases that share
a common genetic cause, which is an expansion of CAG repeats in the coding region of the …

ATP-binding cassette transporter A1 (ABCA1) plays an important role in the regulation of
apolipoprotein E (ApoE) and the biogenesis of high-density lipoprotein (HDL) cholesterol in …