Three major causes of metabolic retinal degenerations and three ways to avoid them

A Kovács-Valasek, T Rák, E Pöstyéni, A Csutak… - International journal of …, 2023 - mdpi.com
An imbalance of homeostasis in the retina leads to neuron loss and this eventually results in
a deterioration of vision. If the stress threshold is exceeded, different protective/survival …

The role of cadre in the community on diabetic retinopathy management and its challenges in low-middle income countries: a scoping review

IS Sadikin, YD Lestari, AA Victor - BMC Public Health, 2024 - Springer
Introduction Diabetes is a serious public health problem, with low-and middle-income
countries (LMICs) bearing over 80% of the burden. Diabetic retinopathy (DR) is one of the …

Elevated retinal fibrosis in experimental myopia is involved in the activation of the PI3K/AKT/ERK signaling pathway

B Bao, J Liu, T Li, Z Yang, G Wang, J Xin, H Bi… - Archives of Biochemistry …, 2023 - Elsevier
Objective This study aimed to investigate the regulatory role of the PI3K/AKT/ERK signaling
pathway in retinal fibrosis in− 6.0 diopter (D) lens-induced myopic (LIM) guinea pigs …

[HTML][HTML] Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors in Diabetic Retinopathy: An Attractive but Elusive Choice for Drug Development

E Pöstyéni, R Gábriel, A Kovács-Valasek - Pharmaceutics, 2024 - mdpi.com
Owing to its promiscuous roles, poly (ADP-ribose) polymerase-1 (PARP-1) is involved in
various neurological disorders including several retinal pathologies. Diabetic retinopathy …

Microglia-endothelial cross-talk regulates diabetes-induced retinal vascular dysfunction through remodeling inflammatory microenvironment

S Ben, Y Ma, Y Bai, Q Zhang, Y Zhao, J Xia, M Yao - Iscience, 2024 - cell.com
Inflammation-mediated crosstalk between neuroglial cells and endothelial cells (ECs) is a
fundamental feature of many vascular diseases. Nevertheless, the landscape of …

Beneficial Effect of Sirolimus-Pretreated Mesenchymal Stem Cell Implantation on Diabetic Retinopathy in Rats

N Kang, JS Jung, J Hwang, SE Park, M Kwon, H Yoon… - Biomedicines, 2024 - mdpi.com
Background: Diabetic retinopathy (DR) is a vision-threatening complication that affects
virtually all diabetic patients. Various treatments have been attempted, but they have many …

[HTML][HTML] Diminished light sensitivities of ON alpha retinal ganglion cells observed in a mouse model of hyperglycemia

Q Wang, C So, C Qiu, T Zhang, K Yang, F Pan - Experimental eye research, 2024 - Elsevier
This study aimed to investigate potential functional changes in retinal ganglion cells (RGCs)
in a mouse model of hyperglycemia and explore possible therapeutic approaches …

Stakeholder insights on cost, quality, and incorporating patient voice in managed care decisions on neovascular (wet) age-related macular degeneration: Findings …

B Flavin, A Schimel, Z Contreras, MH Shannon… - Journal of Managed …, 2024 - jmcp.org
Wet age-related macular degeneration (AMD) is an acquired degeneration of the retina that
can lead to central vision impairment. It is primarily treated with intravitreal injections of …

Contribuții la tratamentul complex al retinopatiei diabetic: Teză de doctor în științe medicale: 321.17-Oftalmologie

V Cușnir - 2024 - repository.usmf.md
Structura tezei: introducere, 3 capitole, concluzii generale și recomandări practice, 101
pagini de text de bază, bibliografie din 201 de titluri, 19 figuri și 7 tabele incluse în text, 5 …

VEGF in Diabetic Retinopathy and Age-Related Macular Degeneration

JZ Heckman, A Tsin, S Villa - 2024 - scholarworks.utrgv.edu
Abstract Vascular Endothelial Growth Factor is a growth factor that plays a significant role in
angiogenesis and vascular permeability. This paper dives into the development of diabetic …