T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …

The most common pediatric malignancy is acute lymphoblastic leukemia (ALL), of which T‐
cell ALL (T‐ALL) comprises 10–15% of cases. T‐ALL arises in the thymus from an immature …

RNA-seq is a promising technology to re-sequence protein coding genes for the
identification of single nucleotide variants (SNV), while simultaneously obtaining information …

T-cell acute lymphocytic leukemia protein 1 (TAL1) is one of the most frequently deregulated
oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). Its deregulation can occur …

Phosphatase and tensin homolog (PTEN)-inactivating mutations and/or deletions are an
independent risk factor for relapse of T-cell acute lymphoblastic leukemia (T-ALL) patients …

Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …

Simple Summary Immature T-cell acute lymphoblastic leukemias englobes a wide range of
low prevalence subtypes, not well identified, that in some cases overlap with myeloid …

The thymus is the primary lymphoid organ where naïve T cells are generated; however, with
the exception of age, the parameters that govern its function in healthy humans remain …

Gene expression studies have consistently identified a HOXA-overexpressing cluster of T-
cell acute lymphoblastic leukemias, but it is unclear whether these constitute a …

Genomic characterization of pediatric acute lymphoblastic leukemia (ALL) has identified
distinct patterns of genes and pathways altered in patients with well‐defined genetic …