Cytochrome P450 2B4 is a microsomal protein with a multi-step reaction cycle similar to that
observed in the majority of other cytochromes P450. The cytochrome P450 2B4-substrate …

P450s have attracted tremendous attention owing to not only their involvement in the
metabolism of drug molecules and endogenous substrates but also the unusual nature of …

The cytochrome P450 monooxygenases (P450s) are thiolate heme proteins that can, often
under physiological conditions, catalyze many distinct oxidative transformations on a wide …

Cytochrome P450s (CYPs) are heme-containing monooxygenases that contribute to an
enormous range of enzymatic function including biosynthetic and detoxification roles. This …

Cytochrome P450 3A4 (CYP3A4) is the dominant xenobiotic-metabolizing enzyme in the
liver and intestine and is involved in the disposition of more than 50% of drugs. Because of …

Besides the canonical pathway of L-arginine oxidation to produce nitric oxide (NO) in vivo,
the nitrate-nitrite-NO pathway has been widely accepted as another source for circulating …

CYP19A1, or aromatase, a cytochrome P450 responsible for estrogen biosynthesis in
humans, is an important therapeutic target for the treatment of breast cancer. There is still …

Abstract Cytochrome P450 17A1 (CYP17A1) is an important drug target for castration
resistant prostate cancer. It is a bi-functional enzyme, catalyzing production of glucocorticoid …

Resonance Raman (RR) spectroscopy is used to help define active site structural responses
of nanodisc-incorporated CYP3A4 to the binding of three substrates: bromocriptine (BC) …

Resonance Raman spectroscopy is used to document, for the first time, a 6 cm− 1 decrease
of the Fe-S stretch by introducing an H-bond donor into the proximal pocket of a cytochrome …