Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …

Besides molecular and phenotypic variations observed in cancer cells, intratumoral
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, but
an effective targeted therapy has not been well-established so far. Considering the lack of …

Background Mitochondrial dynamics underlies malignant transformation, cancer
progression, and response to treatment. Current research presents conflicting evidence for …

Patients with estrogen receptor-positive (ER+) breast cancer, the most common subtype,
remain at risk for lethal metastatic disease years after diagnosis. Recurrence arises partly …

The review focuses on mechanistic evidence for the link between obesity and breast cancer.
According to the IARC study, there is sufficient evidence that obesity is closely related to a …

The integrity of the cytoskeleton is essential to diverse cellular processes such as
phagocytosis and intracellular trafficking. Disruption of the organization and dynamics of the …

Triple-negative breast cancer (TNBC) has an aggressive biological behavior and poor
outcome. Our published study showed that PAI-1 could induce the migration and metastasis …

Obesity is a risk factor in various types of cancer, including breast cancer. The disturbance of
adipose tissue in obesity highly correlates with cancer progression and resistance to …