The Mx dynamin-like GTPases are key antiviral effector proteins of the type I and type III
interferon (IFN) systems. They inhibit several different viruses by blocking early steps of the …

Abstract Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory
Syndrome (MERS) are the most severe coronavirus (CoV)-associated diseases in humans …

Fifty years after the discovery of the mouse Mx1 gene, researchers are still trying to
understand the molecular details of the antiviral mechanisms mediated by Mx proteins. Mx …

Influenza viruses cause annual outbreaks of respiratory tract infection with attack rates of 5–
10%. This means that humans are infected repeatedly with intervals of, on average, 10–20 …

Dynamin 1‐like protein (DNM1L) mediates fission of mitochondria and peroxisomes, and
dysfunction of DNM1L has been implicated in several neurological disorders. To study the …

The human myxovirus resistance protein 1 (MxA) is a key mediator of the interferon-induced
antiviral response against a wide range of viruses. MxA expression is tightly regulated by …

Summary Background The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV,
the causal agent of the severe acute respiratory syndrome epidemic in 2002–03. Although …

Objective Activation of the type 1 interferon (IFN1) pathway is a prominent feature of
dermatomyositis (DM) muscle and may play a role in the pathogenesis of this disease …

Epidemiological studies suggest that low vitamin D levels may increase the risk or severity of
respiratory viral infections. In this study, we examined the effect of vitamin D on respiratory …

Cell-autonomous immunity is essential for host organisms to defend themselves against
invasive microbes. In vertebrates, both the adaptive and the innate branches of the immune …