Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Human accelerated regions (HARs) are the fastest-evolving regions of the human genome,
and many are hypothesized to function as regulatory elements that drive human-specific …

The evolution of advanced cognition in vertebrates is associated with two independent
innovations in the forebrain: the six-layered neocortex in mammals and the dorsal …

Recombinant human erythropoietin (rhEPO) has potent procognitive effects, likely
hematopoiesis-independent, but underlying mechanisms and physiological role of brain …

Adrenal glucocorticoid hormones are crucial for maintenance of homeostasis and
adaptation to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid …

The transcriptome of every cell is orchestrated by the complex network of interaction
between transcription factors (TFs) and their binding sites on DNA. Disruption of this network …

The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar
granule cells and activating the AKT1–mTOR pathway, we increased the caliber of normally …

Disruption of neocortical circuitry and architecture in humans causes numerous
neurodevelopmental disorders. Neocortical cytoarchitecture is orchestrated by various …

In the limbic brain, mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs)
both function as receptors for the naturally occurring glucocorticoids (corticosterone/cortisol) …