Multidrug resistance (MDR) of cancer is a persistent problem in chemotherapy. Scientists
have considered the overexpressed efflux transporters responsible for MDR and …

Enhanced drug extrusion from cells due to the overexpression of the ATP-binding cassette
(ABC) drug transporters inhibits the cytotoxic effects of structurally diverse and …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in Western
countries. Despite novel molecular therapies, the majority of patients with advanced or …

Introduction: The discussion about cancer treatment has a long history. Chemotherapy, one
of the promising approaches in cancer therapy, is limited in the clinic as plenty of factors …

Curcuminoids are major components of Curcuma longa L., which is widely used as spice in
food. This study aimed at identifying whether curcumin, demethoxycurcumin, and …

Multidrug resistance (MDR) is a major obstacle to the successful chemotherapy of solid
tumors. We compared the resistance of the most popular solid tumors, breast …

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Surgical
resection and liver transplantation are still the best options for treatment. Nevertheless, as …

Abstract P‐glycoprotein (P‐gp) is a multidrug resistance (MDR) transporter with unknown
structural details. This macromolecule is normally responsible for extruding xenobiotics from …

背景与目的: 在局部晚期鼻咽癌的治疗中, 含多西他赛新辅助化疗正得到广泛的应用,
其可能进一步提高局部晚期鼻咽癌的生存率. 如果能在化疗前预测鼻咽癌对含多西他赛新辅助 …

A monoclonal antibody (mAb) to P‐glycoprotein (Pgp), UIC2, is used as a targeting moiety
for N‐(2‐hydroxypropyl) methacrylamide (HPMA) copolymer/drug [(meso chlorin e6 mono …