Owing to advances in radiotherapy, the physical properties of radiation can be optimized to
enable individualized treatment; however, optimization is rarely based on biological …

Background Until recently, patients who have the same type and stage of cancer all receive
the same treatment. It has been established, however, that individuals with the same …

In multiple cancer types, high tumor mutational burden (TMB) is associated with longer
survival after treatment with immune checkpoint inhibitors (ICIs). The association of TMB with …

Quasifree one-proton knockout reactions have been employed in inverse kinematics for a
systematic study of the structure of stable and exotic oxygen isotopes at the R 3 B/LAND …

Genetic investigation of tumor heterogeneity and clonal evolution in solid cancers could be
assisted by the analysis of liquid biopsies. However, tumors of various entities might release …

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease arising
from the mucosa of the upper aerodigestive tract. Despite multimodality treatments …

Purpose Definitive radiochemotherapy (RCTX) with curative intent is one of the standard
treatment options in patients with locally advanced head and neck squamous cell carcinoma …

Simple Summary Immunotherapy has prompted a dramatic change in the management of
head and neck squamous cell carcinoma (HNSCC), but the percentage of patients …

Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive
malignancies with complex phenotypic, etiological, biological, and clinical heterogeneities …

Tumor heterogeneity is a well-known prognostic factor in head and neck squamous cell
carcinoma (HNSCC). A major limitation of tissue-and blood-derived tumor markers is the …