Targeted nuclear medicine. Seek and destroy
VM Tolmachev, VI Chernov… - Russian Chemical …, 2022 - iopscience.iop.org
The targeted delivery of radionuclides to tumours holds great promise for diagnosis and
treatment of malignant neoplasms. The development of scaffold proteins has significantly …
treatment of malignant neoplasms. The development of scaffold proteins has significantly …
Protein scaffolds: antibody alternatives for cancer diagnosis and therapy
R Luo, H Liu, Z Cheng - RSC chemical biology, 2022 - pubs.rsc.org
Although antibodies are well developed and widely used in cancer therapy and diagnostic
fields, some defects remain, such as poor tissue penetration, long in vivo metabolic …
fields, some defects remain, such as poor tissue penetration, long in vivo metabolic …
Comparative Preclinical Evaluation of Peptide-Based Chelators for the Labeling of DARPin G3 with 99mTc for Radionuclide Imaging of HER2 Expression in Cancer
M Larkina, E Plotnikov, E Bezverkhniaia… - International Journal of …, 2022 - mdpi.com
Non-invasive radionuclide imaging of human epidermal growth factor receptor type 2
(HER2) expression in breast, gastroesophageal, and ovarian cancers may stratify patients …
(HER2) expression in breast, gastroesophageal, and ovarian cancers may stratify patients …
Feasibility of imaging EpCAM expression in ovarian cancer using radiolabeled DARPin Ec1
A Vorobyeva, E Konovalova, T Xu, A Schulga… - International journal of …, 2020 - mdpi.com
Epithelial cell adhesion molecule (EpCAM) is overexpressed in 55%–75% of ovarian
carcinomas (OC). EpCAM might be used as a target for a treatment of disseminated OC …
carcinomas (OC). EpCAM might be used as a target for a treatment of disseminated OC …
EpCAM-binding DARPins for targeted photodynamic therapy of ovarian cancer
D van den Brand, SAM van Lith, JM de Jong… - Cancers, 2020 - mdpi.com
Ovarian cancer is the most lethal gynecological malignancy due to late detection associated
with dissemination throughout the abdominal cavity. Targeted photodynamic therapy (tPDT) …
with dissemination throughout the abdominal cavity. Targeted photodynamic therapy (tPDT) …
Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with 99mTc and 125I
V Tolmachev, V Bodenko, A Orlova… - Oncology …, 2022 - spandidos-publications.com
The upregulation of epithelial cell adhesion molecule (EpCAM) expression, found in a
substantial fraction of renal cell carcinomas (RCCs), renders it a potential molecular target …
substantial fraction of renal cell carcinomas (RCCs), renders it a potential molecular target …
Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin–Toxin Fusion in a Pancreatic Cancer Xenograft Model
T Xu, A Schulga, E Konovalova, SS Rinne… - International Journal of …, 2023 - mdpi.com
Pancreatic cancer (PC) is one of the most aggressive malignancies. A combination of
targeted therapies could increase the therapeutic efficacy in tumors with heterogeneous …
targeted therapies could increase the therapeutic efficacy in tumors with heterogeneous …
Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [99mTc] Tc (CO) 3-(HE) 3-Ec1 for Visualization of EpCAM-Expressing Lung Cancer
R Zelchan, V Chernov, A Medvedeva, A Rybina… - …, 2024 - pmc.ncbi.nlm.nih.gov
Simple Summary The presented article is devoted to the study of the safety, biodistribution
and absorbed doses of a new radiopharmaceutical for diagnostics and evaluation of the …
and absorbed doses of a new radiopharmaceutical for diagnostics and evaluation of the …
Radionuclide molecular imaging of EpCAM expression in triple-negative breast cancer using the scaffold protein DARPin Ec1
A Vorobyeva, E Bezverkhniaia, E Konovalova… - Molecules, 2020 - mdpi.com
Efficient treatment of disseminated triple-negative breast cancer (TNBC) remains an unmet
clinical need. The epithelial cell adhesion molecule (EpCAM) is often overexpressed on the …
clinical need. The epithelial cell adhesion molecule (EpCAM) is often overexpressed on the …
Influence of the position and composition of radiometals and radioiodine labels on imaging of Epcam expression in prostate cancer model using the DARPin Ec1
SM Deyev, T Xu, Y Liu, A Schulga, E Konovalova… - Cancers, 2021 - mdpi.com
Simple Summary Metastasis-targeting therapy might improve outcomes in oligometastatic
prostate cancer. Epithelial cell adhesion molecule (EpCAM) is overexpressed in 40–60% of …
prostate cancer. Epithelial cell adhesion molecule (EpCAM) is overexpressed in 40–60% of …