Towards development of a novel universal medical diagnostic method: Raman spectroscopy and machine learning

NM Ralbovsky, IK Lednev - Chemical Society Reviews, 2020 - pubs.rsc.org
Many problems exist within the myriad of currently employed screening and diagnostic
methods. Further, an incredibly wide variety of procedures are used to identify an even …

Vibration spectroscopy and body biofluids: Literature review for clinical applications

LB Leal, MS Nogueira, RA Canevari… - … and photodynamic therapy, 2018 - Elsevier
Vibrational spectroscopy techniques such as Raman and IR (infrared) allow real-time, non-
invasive and non-destructive analysis of organic compounds with a good limit-of-detection …

A 3D attention networks for classification of white blood cells from microscopy hyperspectral images

Q Wang, J Wang, M Zhou, Q Li, Y Wen, J Chu - Optics & Laser Technology, 2021 - Elsevier
Peripheral blood smear analysis is a key process for hematologists to reflect condition of
human immune system and one of the earliest clinical applications that benefit from …

Imaging the invisible—Bioorthogonal Raman probes for imaging of cells and tissues

G Azemtsop Matanfack, J Rüger… - Journal of …, 2020 - Wiley Online Library
A revolutionary avenue for vibrational imaging with super‐multiplexing capability can be
seen in the recent development of Raman‐active bioortogonal tags or labels. These tags …

Towards an interpretable classifier for characterization of endoscopic Mayo scores in ulcerative colitis using Raman Spectroscopy

T Kirchberger-Tolstik, P Pradhan, M Vieth… - Analytical …, 2020 - ACS Publications
Ulcerative colitis (UC) is one of the main types of chronic inflammatory diseases that affect
the bowel, but its pathogenesis is yet to be completely defined. Assessing the disease …

Raman microscopy: progress in research on cancer cell sensing

S Elumalai, S Managó, AC De Luca - Sensors, 2020 - mdpi.com
In the last decade, Raman Spectroscopy (RS) was demonstrated to be a label-free, non-
invasive and non-destructive optical spectroscopy allowing the improvement in diagnostic …

Nondestructive identification and accurate isolation of single cells through a chip with Raman optical tweezers

T Fang, W Shang, C Liu, J Xu, D Zhao, Y Liu… - Analytical …, 2019 - ACS Publications
Raman optical tweezers (ROT) as a label-free technique plays an important role in single-
cell study such as heterogeneity of tumor and microbial cells. Herein we designed a chip …

Minimally invasive detection of cancer using metabolic changes in tumor-associated natural killer cells with Oncoimmune probes

D Ishwar, R Haldavnekar, K Venkatakrishnan… - Nature …, 2022 - nature.com
Natural Killer (NK) cells, a subset of innate immune cells, undergo cancer-specific changes
during tumor progression. Therefore, tracking NK cell activity in circulation has potential for …

[HTML][HTML] Discrimination of immune cell activation using Raman micro-spectroscopy in an in-vitro & ex-vivo model

N Chaudhary, TNQ Nguyen, D Cullen… - … Acta Part A: Molecular …, 2021 - Elsevier
Activation and proliferation of immune cells such as lymphocytes and monocytes are
appropriate inflammatory responses to invading pathogens and are key to overcoming an …

Label-free, rapid and highly accurate identification and categorization of leukemia cells via Raman spectroscopy

L Jiang, MX Ren, G Niu, J Shi, X Cao, Y Duan… - Sensors and Actuators B …, 2023 - Elsevier
Leukemia, a highly malignant form of cancer, relies on early diagnosis for effective treatment
and patient survival. Currently, leukemia is diagnosed by manually identifying blood cells …