In silico approaches to identify polyphenol compounds as α-glucosidase and α-amylase inhibitors against type-II diabetes

J Riyaphan, DC Pham, MK Leong, CF Weng - Biomolecules, 2021 - mdpi.com
Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors,
and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α …

Pathophysiology of diabetes mellitus complications: Metabolic events and control

FO Ohiagu, PC Chikezie… - … Research and Therapy, 2021 - bmrat.biomedpress.org
Background: Diabetes mellitus (DM) is a metabolic disorder that is characterized by
hyperglycemia and glucose intolerance, which is associated with impaired insulin secretion …

Natural polyphenols as sirtuin 6 modulators

M Rahnasto-Rilla, J Tyni, M Huovinen, E Jarho… - Scientific reports, 2018 - nature.com
Flavonoids are polyphenolic secondary metabolites synthesized by plants and fungus with
various pharmacological effects. Due to their plethora of biological activities, they have been …

Effect of nano-encapsulated food flavorings on streptozotocin-induced diabetic rats

DM Mohammed, MA Abdelgawad, MM Ghoneim… - Food & Function, 2023 - pubs.rsc.org
Flavors and aromas are widely used in food and pharmaceutical industries to enhance food
palatability. However, it is worth noting that they may also have bioactivity. This study aims to …

Phytochemicals as potential epidrugs in type 2 diabetes mellitus

K Ramirez-Alarcon, M Victoriano, L Mardones… - Frontiers in …, 2021 - frontiersin.org
Type 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent
years due to population age, obesity, and modern sedentary lifestyles. The projections …

Advanced bioinformatics tools in the pharmacokinetic profiles of natural and synthetic compounds with anti-diabetic activity

AM Udrea, G Gradisteanu Pircalabioru, AA Boboc… - Biomolecules, 2021 - mdpi.com
Diabetes represents a major health problem, involving a severe imbalance of blood sugar
levels, which can disturb the nerves, eyes, kidneys, and other organs. Diabes management …

Marine brown algae (Sargassum wightii) derived 9-hydroxyhexadecanoic acid: A promising inhibitor of α-amylase and α-glucosidase with mechanistic insights from …

D Paramasivam, A Meyyazhagan… - South African Journal of …, 2023 - Elsevier
Jeopardized glucose hemostasis leads to cronic metaboic disorder like Diabetes mellitus
and it is predicted to occur in∼ 700 million people in the coming 20 years. Our study aims to …

Exploring antidiabetic potential of a polyherbal formulation Madhurakshak Activ: An in vitro and in silico study

S Paul, M Majumdar - Fitoterapia, 2023 - Elsevier
Madhurakshak Activ (MA), a commercial polyherbal antidiabetic preparation is known to
manage diabetes mellitus (DM) by reducing blood glucose levels. However, lacks …

Metabolic and epigenetic action mechanisms of antidiabetic medicinal plants

S Shanak, B Saad, H Zaid - Evidence‐Based Complementary …, 2019 - Wiley Online Library
Diabetes is a predominant metabolic disease nowadays due to the off‐beam lifestyle of diet
and reduced physical activity. Complications of the illness include the gene‐environment …

[PDF][PDF] In silico ADME-T and molecular docking study of phytoconstituents from Tithonia diversifolia (Hemsl.) A. Gray on various targets of diabetic nephropathy

OR Adianingsih, U Khasanah, KD Anandhy… - J Pharm Pharmacogn …, 2022 - academia.edu
Abstract Context: Tithonia diversifolia (Hemsl.) A. Gray has been known for treatment of
diabetes mellitus, yet its mechanism as anti-diabetic has not been defined. There are …