Small angle X-ray diffraction as a tool for structural characterization of muscle disease

W Ma, TC Irving - International Journal of Molecular Sciences, 2022 - mdpi.com
Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …

A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly

Q Lyu, S Gong, JG Lees, J Yin, LW Yap… - Nature …, 2022 - nature.com
Time-lapse mechanical properties of stem cell derived cardiac organoids are important
biological cues for understanding contraction dynamics of human heart tissues …

High-resolution multi-z confocal microscopy with a diffractive optical element

B Zhao, M Koyama, J Mertz - Biomedical Optics Express, 2023 - opg.optica.org
There has been recent interest in the development of fluorescence microscopes that provide
high-speed volumetric imaging for life-science applications. For example, multi-z confocal …

Nonclinical evaluation of chronic cardiac contractility modulation on 3D human engineered cardiac tissues

TK Feaster, JK Ewoldt, A Avila… - Journal of …, 2024 - Wiley Online Library
Introduction Cardiac contractility modulation (CCM) is a medical device‐based therapy
delivering non‐excitatory electrical stimulations to the heart to enhance cardiac function in …

Effect of Electrical Stimulation on Spontaneously Beating Dynamics of Cardiac Tissues: An Analysis Using Digital Image Correlation

L Lou, AS Rubfiaro, J He… - Advanced Materials …, 2021 - Wiley Online Library
Electrical pacing/stimulations (EP) have been widely adopted to promote the maturation of
hiPSC‐derived cardiomyocytes. However, there is a debate about their functions and …

[HTML][HTML] Multiplex Single-Cell Bioprinting for Engineering of Heterogeneous Tissue Constructs with Subcellular Spatial Resolution

HR Helms, KA Oyama, JP Ware, SD Ibsen… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Tissue development, function, and disease are largely driven by the spatial organization of
individual cells and their cell-cell interactions. Precision engineered tissues with single-cell …

Structural maturation of myofilaments in engineered 3D cardiac microtissues characterized using small angle x-ray scattering

G van Dover, J Javor, JK Ewoldt, M Zhernenkov… - Physical …, 2024 - iopscience.iop.org
Understanding the structural and functional development of human-induced pluripotent stem-
cell-derived cardiomyocytes (hiPSC-CMs) is essential to engineering cardiac tissue that …

[图书][B] Advances in Bioreactor Design and Multi-Dimensional Analysis for Assessing Maturation Phenotype of Human Engineered Cardiac Tissues

CC van Neste - 2022 - search.proquest.com
Heart failure remains the world's leading cause of death worldwide, with limited treatment
options aside from palliation and a desperate need for effective preclinical models. The …

Characterization of the Subcellular Structure of Engineered Cardiomyocytes Using Small Angle X-Ray Scattering

GR van Dover - 2023 - search.proquest.com
The structural and functional development of human induced pluripotent stem cell-derived
cardiomyocytes (hiPSC-CMs) is essential to understand in order to enable pharmaceutical …

BioMEMS for cardiac tissue monitoring and maturation

J Javor - 2021 - search.proquest.com
Diseases of the heart have been the most common cause of death in the United States since
the middle of the 20th century. The development of engineered cardiac tissue over the last …