Mitochondria, organelles that harbor their own circular genomes, are critical for energy
production and homeostasis maintenance in eukaryotic cells. Recent studies discovered …

Cancer is a complex disease caused by genetic and epigenetic alterations in the control of
cell division. Findings from the field of cancer genomics and epigenomics have increased …

Abstract Although N4-acetylcytidine (ac4C) modification affects the stability and translation
of mRNA, it is unknown whether it exists in noncoding RNAs, and its biological function is …

Bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoblast
function play critical roles in bone formation, which is a highly regulated process. Long …

Summary The Central Dogma of the flow of genetic information is arguably the crowning
achievement of 20 th century molecular biology. Reversing the flow of information from RNA …

Abstract Hexavalent chromium [Cr (VI)] is a common environmental pollutant and chronic
exposure to Cr (VI) causes lung cancer in humans, however, the mechanism of Cr (VI) …

Background Tumor-associated macrophages (TAMs) are a major component of the tumor
microenvironment (TME) and exert an important role in tumor progression. Due to the …

Though long non-coding RNAs (lncRNAs) represent a substantial fraction of the Pol II
transcripts in multicellular animals, only a few have known functions. Here we report that the …

Background Limited response to programmed death ligand-1 (PD-L1)/programmed death 1
(PD-1) immunotherapy is a major hindrance of checkpoint immunotherapy in non-small cell …

Long non-coding RNAs (lncRNAs) have been identified as master gene regulators through
various mechanisms such as transcription, translation, protein modification and RNA-protein …