Notch signalling is involved in many aspects of cancer biology, including angiogenesis,
tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can …

Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …

Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

During the past decade, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …

Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells
within different tumor types and is responsible for treatment failure. Cancer stem cells …

Despite the advancement of treatment modalities, many cancer patients experience tumor
recurrence and metastasis at regional or distant sites. Evolving understanding of tumor …

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago,
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …

Notch signaling plays an important role in development and cell fate determination, and it is
deregulated in human hematologic malignancies and solid tumors. This review includes a …

Chemokines, which have chemotactic abilities, are comprised of a family of small cytokines
with 8-10 kilodaltons. Chemokines work in immune cells by trafficking and regulating cell …