Defining the riddle in order to solve it: there is more than one “Parkinson's disease”
Background More than 200 years after James Parkinsondescribed a clinical syndrome
based on his astute observations, Parkinson's disease (PD) has evolved into a complex …
based on his astute observations, Parkinson's disease (PD) has evolved into a complex …
Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults
Z Kovarik, G Moshitzky, N Maček Hrvat… - Journal of …, 2024 - Wiley Online Library
This review presents recent studies of the chemical and molecular regulators of
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …
Sex‐specific declines in cholinergic‐targeting tRNA fragments in the nucleus accumbens in Alzheimer's disease
Abstract Introduction Females with Alzheimer's disease (AD) suffer accelerated dementia
and loss of cholinergic neurons compared to males, but the underlying mechanisms are …
and loss of cholinergic neurons compared to males, but the underlying mechanisms are …
Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders
Y Chen, Z Yang, B Nian, C Yu, D Maimaiti… - Neuropsychiatric …, 2024 - Taylor & Francis
Organophosphates (OPs) refers to a diverse group of phosphorus-containing organic
compounds; they are widely used all over the world and have had an important beneficial …
compounds; they are widely used all over the world and have had an important beneficial …
The impact of microRNAs on mitochondrial function and immunity: Relevance to Parkinson's disease
BFS Guedes, SM Cardoso, AR Esteves - Biomedicines, 2023 - mdpi.com
Parkinson's Disease (PD), the second most common neurodegenerative disorder, is
characterised by the severe loss of dopaminergic neurons in the Substantia Nigra pars …
characterised by the severe loss of dopaminergic neurons in the Substantia Nigra pars …
Assessment of tRNAThr and tRNAGln Variants and Mitochondrial Functionality in Parkinson's Disease (PD) Patients of Tamil Nadu Population
D Venkatesan, M Iyer, N Raj… - Journal of Molecular …, 2023 - Springer
Parkinson's disease (PD) is speculated with genetic and environmental factors. At molecular
level, the mitochondrial impact is stated to be one of the causative reasons for PD. In this …
level, the mitochondrial impact is stated to be one of the causative reasons for PD. In this …
tRNA‐derived fragments: Unveiling new roles and molecular mechanisms in cancer progression
J Lu, P Zhu, X Zhang, L Zeng, B Xu… - International Journal of …, 2024 - Wiley Online Library
Abstract tRNA‐derived fragments (tRFs) are novel small noncoding RNAs (sncRNAs) that
range from approximately 14 to 50 nt. They are generated by the cleavage of mature tRNAs …
range from approximately 14 to 50 nt. They are generated by the cleavage of mature tRNAs …
Inversely Regulated Inflammation-Related Processes Mediate Anxiety–Obesity Links in Zebrafish Larvae and Adults
Anxiety and metabolic impairments are often inter-related, but the underlying mechanisms
are unknown. To seek RNAs involved in the anxiety disorder–metabolic disorder link, we …
are unknown. To seek RNAs involved in the anxiety disorder–metabolic disorder link, we …
Control systems theory revisited: new insights on the brain clocks of time-to-action
To outline the complex biological rhythms underlying the time-to-action of goal-oriented
behavior in the adult brain, we employed a Boolean Algebra model based on Control …
behavior in the adult brain, we employed a Boolean Algebra model based on Control …
Transfer RNA fragments, from structure to function
Transfer RNA molecules (tRNAs) are produced from numerous nuclear and mitochondrial
genes and are primarily involved in bringing specific amino acid residues to polyribosomes …
genes and are primarily involved in bringing specific amino acid residues to polyribosomes …