Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

The management of patients with autoimmune rheumatic diseases such as rheumatoid
arthritis (RA) remains a significant challenge. Often the rheumatologist is restricted to …

Redox degenerative reactions of the biological system inevitably produce reactive oxygen
species (ROS) and their derivatives. Oxidative stress is the result of an imbalance in pro …

Neuroinflammation constitutes a fundamental process involved in the progression of several
neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease …

Oxidative stress has been related increasingly to the onset and/or progression of a growing
number of human diseases. However, large studies on supplementation with anti-oxidants …

CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic
chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis …

The free radical-mediated damage to proteins results in the modification of amino acid
residues, cross-linking of side chains and fragmentation. l-Tyrosine and protein bound …

The free radical nitric oxide (NO•) exerts biological effects through the direct and reversible
interaction with specific targets (eg soluble guanylate cyclase) or through the generation of …

Protein tyrosine nitration (PTN) is a post-translational modification occurring under the action
of a nitrating agent. Tyrosine is modified in the 3-position of the phenolic ring through the …