Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment

Q Gao, J Feng, W Liu, C Wen, Y Wu, Q Liao… - Advanced drug delivery …, 2022 - Elsevier
The therapeutic limitations such as insufficient efficacy, drug resistance, metastasis, and
undesirable side effects are frequently caused by the long duration monotherapy based on …

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

MA Hannan, MA Rahman, AAM Sohag, MJ Uddin… - Nutrients, 2021 - mdpi.com
Mounting evidence support the potential benefits of functional foods or nutraceuticals for
human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical …

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

EM Yimer, KB Tuem, A Karim… - Evidence‐Based …, 2019 - Wiley Online Library
The seed of Nigella sativa (N. sativa) has been used in different civilization around the world
for centuries to treat various animal and human ailments. So far, numerous studies …

[HTML][HTML] Thymoquinone: A novel strategy to combat cancer: A review

M Imran, A Rauf, IA Khan, M Shahbaz… - Biomedicine & …, 2018 - Elsevier
The higher consumption of fruit, herbs, spices, and vegetables is well known and practical
strategy to cure human cancers owing to their presence of bioactive compounds. Among …

Synergistic effects of plant derivatives and conventional chemotherapeutic agents: an update on the cancer perspective

R Pezzani, B Salehi, S Vitalini, M Iriti, FA Zuñiga… - Medicina, 2019 - mdpi.com
Synergy is a process in which some substances cooperate to reach a combined effect that is
greater than the sum of their separate effects. It can be considered a natural “straight” …

Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives

E Khatoon, K Banik, C Harsha, BL Sailo… - Seminars in Cancer …, 2022 - Elsevier
Despite significant advancements made in the treatment of cancer during the past several
decades, it remains one of the leading causes of death worldwide killing approximately 9.6 …

Dietary natural products for prevention and treatment of breast cancer

Y Li, S Li, X Meng, RY Gan, JJ Zhang, HB Li - Nutrients, 2017 - mdpi.com
Breast cancer is the most common cancer among females worldwide. Several
epidemiological studies suggested the inverse correlation between the intake of vegetables …

[HTML][HTML] Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

MA Khan, M Tania, S Fu, J Fu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this
review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of …

Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa

AF Majdalawieh, MW Fayyad… - Critical reviews in food …, 2017 - Taylor & Francis
Over the past two decades, studies have documented the wide-range anti-cancer effects of
Nigella sativa, known as black seed or black cumin. Thymoquinone (TQ), its major active …

Combating breast cancer using combination therapy with 3 phytochemicals: Piperine, sulforaphane, and thymoquinone

MZ Aumeeruddy, MF Mahomoodally - Cancer, 2019 - Wiley Online Library
Despite the significant advances in screening methods for early diagnosis, breast cancer
remains a global threat and continues to be the leading cancer diagnosed in women …