The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …

Clinical successes demonstrated by chimeric antigen receptor T-cell immunotherapy have
facilitated further development of T-cell immunotherapy against wide variety of diseases …

Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin …

The induced pluripotent stem cell (i PSC) technology is instrumental in advancing the fields
of disease modeling and cell transplantation. We herein discuss the various issues …

Human mucosal-associated invariant T (MAIT) cells are characterized by their expression of
an invariant TCR α chain Vα7. 2-Jα33/Jα20/Jα12 paired with a restricted TCR β chain. MAIT …

The promising clinical results obtained with engineered T cells, including chimeric antigen
receptor (CAR) therapy, call for further advancements to facilitate and broaden their …

CD1-and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …

CD8+ Tregs have been long described and significant progresses have been made about
their phenotype, their functional mechanisms, and their suppressive ability compared to …

Abstract Background and Aim: Ulcerative colitis (UC) is a chronic, relapsing and remitting,
inflammatory disorder of the large intestine. Mucosal associated invariant T (MAIT) cells are …