Podocytes are a major component of the glomerular blood filtration barrier, and alterations to
the morphology of their unique actin-based foot processes (FP) are a common feature of …

Oxidized lipids initiate and modulate the inflammatory cellular events in the arterial wall and
the formation of macrophage foam cells. CD36 mediates the cellular uptake of ox-LDL …

Increasing evidence indicates that long noncoding RNAs (lncRNAs) are involved in diverse
biological process. Mouse maternal expressed gene 3 (Meg3) is an imprinted gene and …

Increased podocyte detachment begins immediately after kidney transplantation and is
associated with long-term allograft failure. We hypothesized that cell-specific transcriptional …

Aims: Oxidative stress plays a role in mediating podocyte injury and proteinuria. However,
the underlying mechanism remains poorly understood. In this study, we investigated the …

Recent studies have demonstrated the role of insulin resistance in renal injury related to
obesity, with hyperfiltration leading to glomerulomegaly in a pattern similar to that found in …

Ninety-one years ago insulin was discovered, which was one of the most important medical
discoveries in the past century, transforming the lives of millions of diabetic patients. Initially …

Nephrin (NPHS1) has been described as an important structural protein of kidney
podocytes. Mutations in this gene lead to the Finnish-type congenital nephrotic syndrome …

Assembly of signaling molecules into micrometer-sized clusters is driven by multivalent
protein-protein interactions, such as those found within the nephrin–Nck (Nck1 or Nck2) …

Diabetes is the leading cause of microalbuminuria and end-stage renal failure in industrial
countries. Disruption of the filtration barrier, seen in almost all nephrotic diseases and …