The methods for the culture and cardiomyocyte differentiation of human embryonic stem
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …

Biohybrid systems have been developed to better understand the design principles and
coordination mechanisms of biological systems. We consider whether two functional …

Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst.
ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as …

Our study was conducted to investigate whether cadherin‐5 (CDH5), a vascular endothelial
cell adhesion glycoprotein, could facilitate the differentiation of human induced pluripotent …

The composite material-like extracellular matrix (ECM) in the sinoatrial node (SAN) supports
the native pacemaking cardiomyocytes (PCMs). To test the roles of SAN ECM in the PCM …

Cardiac biological pacing (BP) is one of the future directions for bradyarrhythmias
intervention. Currently, cardiac pacemaker cells (PCs) used for cardiac BP are mainly …

The cardiovascular system is one of the most complex and indispensable systems in the
body and is responsible for the circulation of nutrition, oxygen, carbon dioxide, hormones to …

Congenital heart disease (CHD) is the most common cause of infant death associated with
birth defects. Recent next-generation genome sequencing has uncovered novel genetic …

Patient-derived pluripotent stem cells (PSCs) have greatly transformed the current
understanding of human heart development and cardiovascular disease. Cardiomyocytes …

Directed cardiomyogenesis from human induced pluripotent stem cells (hiPSCs) has been
greatly improved in the last decade but directed differentiation to pacemaking …