Immune reactions to small molecular compounds, such as drugs, can cause a variety of
diseases involving the skin, liver, kidney, and lungs. In many drug hypersensitivity reactions …

Diagnosis of drug hypersensitivity is difficult, as an enormous amount of different drugs can
elicit various immune‐mediated diseases with distinct pathomechanism. The lymphocyte …

Drug hypersensitivity reactions (DHR s) are a matter of great concern, both for outpatient
and in hospital care. The evaluation of these patients is complex, because in vivo tests have …

Background Acute generalized exanthematous pustulosis (AGEP) is a disease
characterized by the rapid occurrence of many sterile, nonfollicular pustules usually arising …

To cite this article: Cernadas JR, Brockow K, Romano A, Aberer W, Torres MJ, Bircher A,
Campi P, Sanz ML, Castells M, Demoly P, Pichler WJ, for the European Network of Drug …

Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by
the known mechanisms of action of the offending agent, do not occur at any dose in most …

Comprehensive practical guidance for the evaluation and management of patients with drug
allergy and hypersensitivity are lacking. The authors have aimed to create such a document …

The objective of these guidelines is to ensure efficient and effective clinical practice. The
panel of experts who produced this consensus document developed a research protocol …

Noncovalent drug presentation leads to the stimulation of immune cells, namely T-cells. The
drug needs two surface molecules (one inert serving as a scaffold, major histocompatibility …

All iodinated contrast media (CM) are known to cause both immediate (≤ 1 h) and
nonimmediate (> 1 h) hypersensitivity reactions. Although for most immediate reactions an …