[HTML][HTML] Centrioles, centrosomes, and cilia in health and disease

EA Nigg, JW Raff - Cell, 2009 - cell.com
Centrioles are barrel-shaped structures that are essential for the formation of centrosomes,
cilia, and flagella. Here we review recent advances in our understanding of the function and …

Chapter two intraflagellar transport (IFT): role in ciliary assembly, resorption and signalling

LB Pedersen, JL Rosenbaum - Current topics in developmental biology, 2008 - Elsevier
Cilia and flagella have attracted tremendous attention in recent years as research
demonstrated crucial roles for these organelles in coordinating a number of physiologically …

Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas

Y Hu, QI Wu, S Ma, T Ma, L Shan… - Proceedings of the …, 2017 - National Acad Sciences
Phenotypic convergence between distantly related taxa often mirrors adaptation to similar
selective pressures and may be driven by genetic convergence. The giant panda …

Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis

KN Schmidt, S Kuhns, A Neuner, B Hub… - Journal of Cell …, 2012 - rupress.org
Cilia formation is a multi-step process that starts with the docking of a vesicle at the distal
part of the mother centriole. This step marks the conversion of the mother centriole into the …

Cep164, a novel centriole appendage protein required for primary cilium formation

S Graser, YD Stierhof, SB Lavoie, OS Gassner… - The Journal of cell …, 2007 - rupress.org
Primary cilia (PC) function as microtubule-based sensory antennae projecting from the
surface of many eukaryotic cells. They play important roles in mechano-and chemosensory …

Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells

AL Firth, CT Dargitz, SJ Qualls… - Proceedings of the …, 2014 - National Acad Sciences
Despite therapeutic advancement, pulmonary disease still remains a major cause of
morbidity and mortality around the world. Opportunities to study human lung disease either …

The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly

JA Follit, RA Tuft, KE Fogarty… - Molecular biology of the …, 2006 - Am Soc Cell Biol
Eukaryotic cilia are assembled via intraflagellar transport (IFT) in which large protein
particles are motored along ciliary microtubules. The IFT particles are composed of at least …

Primary cilia, ciliogenesis and the actin cytoskeleton: a little less resorption, a little more actin please

CEL Smith, AVR Lake, CA Johnson - Frontiers in cell and …, 2020 - frontiersin.org
Primary cilia are microtubule-based organelles that extend from the apical surface of most
mammalian cells, forming when the basal body (derived from the mother centriole) docks at …

The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia

A Molla-Herman, R Ghossoub, T Blisnick… - Journal of cell …, 2010 - journals.biologists.com
Cilia and flagella are eukaryotic organelles involved in multiple cellular functions. The
primary cilium is generally non motile and found in numerous vertebrate cell types where it …

Role of TRP channels in the cardiovascular system

Z Yue, J Xie, AS Yu, J Stock, J Du… - American Journal of …, 2015 - journals.physiology.org
The transient receptor potential (TRP) superfamily consists of a large number of
nonselective cation channels with variable degree of Ca2+-permeability. The 28 mammalian …