Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …

We determined the crystal structure of the extracellular domain of the mouse nicotinic
acetylcholine receptor (nAChR) α1 subunit bound to α-bungarotoxin at 1.94 Å resolution …

Since their discovery, nicotinic acetylcholine receptors (nAChRs) have been extensively
studied to understand their function, as well as the consequence of alterations leading to …

Gamma-aminobutyric acid (GABA) is the most important inhibitory transmitter in the central
nervous system. Most of the actions of GABA are mediated by GABAA receptors. These are …

The crystal structure of the extracellular domain (ECD) of the pentameric ligand-gated ion-
channel from Gloeobacter violaceus (GLIC) was solved at neutral pH at 2.3 Å resolution in …

The majority of patients with myasthenia gravis (MG), an organ-specific autoimmune
disease, harbor autoantibodies that attack the nicotinic acetylcholine receptor (nAChR-Abs) …

The nicotinic acetylcholine receptor (nAChR) is a major target of autoantibodies in
myasthenia gravis (MG), an autoimmune disease that causes neuromuscular transmission …

The N-terminal extracellular domain (amino acids 1–210; hα-(1–210)) of the α subunit of the
human muscle nicotinic acetylcholine receptor (AChR), bearing the binding sites for …

Antibodies against the acetylcholine receptor (AChR) are the main pathogenic factor in
myasthenia gravis (MG). Clinical improvement correlates well with a reduction in levels of …

The antibody‐mediated autoimmune response to α1 muscle nicotinic acetylcholine
receptors that causes myasthenia gravis is one of the best characterized autoimmune …