Nanomaterial-based drug delivery systems for pain treatment and relief: from the delivery of a single drug to co-delivery of multiple therapeutics

Y Xu, X Dong, H Xu, P Jiao, LX Zhao, G Su - Pharmaceutics, 2023 - mdpi.com
The use of nanomaterials in drug delivery systems for pain treatment is becoming
increasingly common. This review aims to summarize how nanomaterial-based drug …

Update on the role of paravertebral blocks for thoracic surgery: are they worth it?

DJ Daly, PS Myles - Current Opinion in Anesthesiology, 2009 - journals.lww.com
There is good evidence that paravertebral block can provide acceptable pain relief
compared with thoracic epidural analgesia for thoracotomy. Important side-effects such as …

Fusogenic Liposomes Increase the Antimicrobial Activity of Vancomycin Against Staphylococcus aureus Biofilm

AB Scriboni, VM Couto, LNM Ribeiro… - Frontiers in …, 2019 - frontiersin.org
Objective: The aim of the present study was to encapsulate vancomycin in different
liposomal formulations and compare the in vitro antimicrobial activity against …

Prolonged duration local anesthesia with minimal toxicity

H Epstein-Barash, I Shichor, AH Kwon… - Proceedings of the …, 2009 - National Acad Sciences
Injectable local anesthetics that would last for many days could have a marked impact on
periprocedural care and pain management. Formulations have often been limited in …

Micro and nanosystems for delivering local anesthetics

E de Paula, CMS Cereda, LF Fraceto… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: One of the most common strategies for pain control during and after surgical
procedures is the use of local anesthetics. Prolonged analgesia can be safely achieved with …

New “drug-in cyclodextrin-in deformable liposomes” formulations to improve the therapeutic efficacy of local anaesthetics

F Maestrelli, ML González-Rodríguez… - International journal of …, 2010 - Elsevier
The combined approach of cyclodextrin complexation and entrapment in liposomes was
investigated to develop a topical formulation of local anaesthetics. For both benzocaine …

Liposomal lidocaine gel for topical use at the oral mucosa: characterization, in vitro assays and in vivo anesthetic efficacy in humans

M Franz-Montan, D Baroni, G Brunetto… - Journal of liposome …, 2015 - Taylor & Francis
Objective: To characterize liposomal-lidocaine formulations for topical use on oral mucosa
and to compare their in vitro permeation and in vivo anesthetic efficacy with commercially …

Fresh carrier for an old topical local anesthetic: benzocaine in nanostructured lipid carriers

AD Souza, GH Rodrigues da Silva… - ACS Biomaterials …, 2024 - ACS Publications
Nanostructured lipid carriers (NLC) have emerged as innovative drug delivery systems,
offering distinct advantages over other lipid-based carriers, such as liposomes and solid …

Current progress and challenges of nanoparticle-based therapeutics in pain management

V Andreu, M Arruebo - Journal of Controlled Release, 2018 - Elsevier
Pain is a widespread and growing health problem worldwide that exerts a considerable
social and economic impact on both patients and healthcare systems and, therefore, on …

Preparation and characterization of poly (ε-caprolactone) nanospheres containing the local anesthetic lidocaine

EVR Campos, NFS de Melo, VA Guilherme… - Journal of …, 2013 - Elsevier
The objective of this work was to develop a modified release system for the local anesthetic
lidocaine (LDC), using poly (ε‐caprolactone)(PCL) nanospheres (NSs), to improve the …