The mammalian brain contains unusually high levels of d‐serine, ad‐amino acid previously
thought to be restricted to some bacteria and insects. In the last few years, studies from …

Synaptic plasticity consists in a change in synaptic strength that is believed to be the basis of
learning and memory. Synaptic plasticity has been for a very long period of time a hallmark …

Global brain state dynamics regulate plasticity in local cortical circuits, but the underlying
cellular and molecular mechanisms are unclear. Here, we demonstrate that astrocyte Ca2+ …

d-Serine modulates N-methyl d-aspartate receptors (NMDARs) and regulates synaptic
plasticity, neurodevelopment, and learning and memory. However, the primary site of d …

Alzheimer′ s disease (AD) is the most common form of dementia in the elderly. Memory
loss in AD is increasingly attributed to soluble oligomers of the amyloid‐β peptide (AβOs) …

Excitotoxicity has been implicated in the pathogenesis of amyotrophic lateral sclerosis
(ALS). More recently, glial involvement has been shown to be essential for ALS‐related …

d-Serine is a coagonist of N-methyl-d-aspartate (NMDA) receptors that occurs at high levels
in the brain. Biosynthesis of d-serine is carried out by serine racemase, which converts l-to d …

N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an
important role in learning and memory, and are critical for spatial memory. These receptors …

N-methyl-d-aspartate receptors (NMDARs) subserve numerous neurophysiological and
neuropathological processes in the cerebral cortex. Their activation requires the binding of …

Abstract d-Serine (d-Ser) is an endogenous co-agonist for NMDA receptors and regulates
neurotransmission and synaptic plasticity in the forebrain. d-Ser is also found in the …