Background Gait impairment contributes to falls and frailty. Some studies suggest that
cerebral small vessel disease (CSVD) is associated with gait impairment in the general …

Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …

Biological aging is the gradual, progressive decline in system integrity that occurs with
advancing chronological age, causing morbidity and disability. Measurements of the pace of …

Sarcopenia has an insidious start that can induce physical malfunction, raise the risk of falls,
disability, and mortality in the old, severely impair the aged persons' quality of life and …

Sarcopenia is an important public health problem, characterized by age-related loss of
muscle mass and muscle function. It is a precursor of physical frailty, mobility limitation, and …

This study aimed to investigate the association between a virtual reality (VR) intervention
program and cognitive, brain and physical functions in high-risk older adults. In a …

Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …

Objectives To describe the normative values of sarcopenia among community-dwelling
adults (≥ 21 years of age); compare the prevalence of sarcopenia using Asian Working …

The substantial decline in skeletal muscle mass, strength, and gait speed is a sign of severe
sarcopenia, which may partly depend on genetic risk factors. So far, hundreds of genome …