Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

Excessive ethanol exposure is detrimental to the brain. The developing brain is particularly
vulnerable to ethanol such that prenatal ethanol exposure causes fetal alcohol spectrum …

As a classically known mitogen, fibroblast growth factor 1 (FGF1) has been found to exert
other pleiotropic functions such as metabolic regulation and myocardial protection. Here, we …

AMPK, a serine/threonine protein kinase, has proven to be an important positive regulator of
autophagy, which is a key factor in the regulation of cardiac hypertrophy. Thus, we explored …

Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both
mitochondrial function and cellular processes outside of the mitochondria. The importance of …

Although dietary α-linolenic acid (ALA) or linolenic acid (LA) intake was reported to be
epidemiologically associated with a lower prevalence of hypertension, recent clinical trials …

Background Binge drinking leads to compromised mitochondrial integrity and contractile
function in the heart although little effective remedy is readily available. Given the possible …

Methods: Wild type Friend virus B (FVB) and ALDH2 transgenic mice were placed on a 4%
alcohol or control diet for 12 weeks. Serum levels of aspartate aminotransferase (AST) …

Alcoholism is accompanied with a high incidence of cardiac morbidity and mortality due to
the development of alcoholic cardiomyopathy, manifested as dilation of one or both …

Chronic excessive drinking leads to myocardial contractile dysfunction and dilated
cardiomyopathy, where ethanol toxicity plays an essential role. Cytochrome P450 (CYP) …