Role of PI3K-AKT-mTOR pathway as a pro-survival signaling and resistance-mediating mechanism to therapy of prostate cancer
T Pungsrinont, J Kallenbach, A Baniahmad - International journal of …, 2021 - mdpi.com
Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …
gold standard options for treating prostate cancer (PCa). These are initially effective, as …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
AR and PI3K/AKT in prostate cancer: a tale of two interconnected pathways
E Tortorella, S Giantulli, A Sciarra, I Silvestri - International Journal of …, 2023 - mdpi.com
Prostate cancer (PCa) is the most common cancer in men. The androgen receptor (AR) has
a pivotal role in the pathogenesis and progression of PCa. Many therapies targeting AR …
a pivotal role in the pathogenesis and progression of PCa. Many therapies targeting AR …
Therapeutic strategies to target the androgen receptor
The androgen receptor (AR) plays a key role in the maintenance of muscle and bone and
the support of male sexual-related functions, as well as in the progression of prostate …
the support of male sexual-related functions, as well as in the progression of prostate …
Molecular subtypes of prostate cancer
K Arora, CE Barbieri - Current Oncology Reports, 2018 - Springer
Abstract Purpose of Review This review will examine the taxonomy of PCa subclasses
across disease states, explore the relationship among specific alterations, and highlight …
across disease states, explore the relationship among specific alterations, and highlight …
[HTML][HTML] Modulating androgen receptor-driven transcription in prostate cancer with selective CDK9 inhibitors
Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation
therapies but frequently remain dependent on oncogenic transcription driven by the …
therapies but frequently remain dependent on oncogenic transcription driven by the …
Small molecules targeting the disordered transactivation domain of the androgen receptor induce the formation of collapsed helical states
Intrinsically disordered proteins, which do not adopt well-defined structures under
physiological conditions, are implicated in many human diseases. Small molecules that …
physiological conditions, are implicated in many human diseases. Small molecules that …
Acne transcriptomics: fundamentals of acne pathogenesis and isotretinoin treatment
BC Melnik - Cells, 2023 - mdpi.com
This review on acne transcriptomics allows for deeper insights into the pathogenesis of acne
and isotretinoin's mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin …
and isotretinoin's mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin …
A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance
A Alegre-Martí, A Jiménez-Panizo… - Science …, 2023 - science.org
Mutations of the androgen receptor (AR) associated with prostate cancer and androgen
insensitivity syndrome may profoundly influence its structure, protein interaction network …
insensitivity syndrome may profoundly influence its structure, protein interaction network …
Targeting CDK9 with selective inhibitors or degraders in tumor therapy: an overview of recent developments
L Xiao, Y Liu, H Chen, L Shen - Cancer Biology & Therapy, 2023 - Taylor & Francis
As a catalytic subunit of the positive transcription elongation factor b (P-TEFb), cyclin-
dependent kinase 9 (CDK9) has been demonstrated to contribute to carcinogenesis. This …
dependent kinase 9 (CDK9) has been demonstrated to contribute to carcinogenesis. This …