Protein leverage: theoretical foundations and ten points of clarification

D Raubenheimer, SJ Simpson - Obesity, 2019 - Wiley Online Library
Much attention has been focused on fats and carbohydrates as the nutritional causes of
energy overconsumption and obesity. In 2003, a model of intake regulation was proposed in …

Protein appetite as an integrator in the obesity system: the protein leverage hypothesis

D Raubenheimer, SJ Simpson - … Transactions of the …, 2023 - royalsocietypublishing.org
Despite the large volume and extensive range of obesity research, there is substantial
disagreement on the causes and effective preventative strategies. We suggest the field will …

The share of ultra-processed foods determines the overall nutritional quality of diets in Brazil

ML da Costa Louzada, CZ Ricardo, EM Steele… - Public health …, 2018 - cambridge.org
ObjectiveTo estimate the dietary share of ultra-processed foods and to determine its
association with the overall nutritional quality of diets in Brazil. DesignCross-sectional …

Estimated Effects of Future Atmospheric Concentrations on Protein Intake and the Risk of Protein Deficiency by Country and Region

DE Medek, J Schwartz, SS Myers - Environmental Health …, 2017 - ehp.niehs.nih.gov
Background: Crops grown under elevated atmospheric CO 2 concentrations (eCO 2) contain
less protein. Crops particularly affected include rice and wheat, which are primary sources of …

Dietary protein to carbohydrate ratio and caloric restriction: comparing metabolic outcomes in mice

SM Solon-Biet, SJ Mitchell, SCP Coogan, VC Cogger… - Cell reports, 2015 - cell.com
Both caloric restriction (CR) and low-protein, high-carbohydrate (LPHC) ad-libitum-fed diets
increase lifespan and improve metabolic parameters such as insulin, glucose, and blood …

Putting the balance back in diet

SJ Simpson, DG Le Couteur, D Raubenheimer - Cell, 2015 - cell.com
The notion of dietary balance is fundamental to health yet is not captured by focusing on the
intake of energy or single nutrients. Advances in nutritional geometry have begun to unravel …

Defining the nutritional and metabolic context of FGF21 using the geometric framework

SM Solon-Biet, VC Cogger, T Pulpitel, M Heblinski… - Cell metabolism, 2016 - cell.com
Summary Fibroblast growth factor 21 (FGF21) is the first known endocrine signal activated
by protein restriction. Although FGF21 is robustly elevated in low-protein environments …

Nutritional physiology and ecology of wildlife in a changing world

K Birnie-Gauvin, KS Peiman… - Conservation …, 2017 - academic.oup.com
Over the last century, humans have modified landscapes, generated pollution and provided
opportunities for exotic species to invade areas where they did not evolve. In addition …

The multidimensional nutritional niche

GE Machovsky-Capuska, AM Senior… - Trends in Ecology & …, 2016 - cell.com
The dietary generalist–specialist distinction plays a pivotal role in theoretical and applied
ecology, conservation, invasion biology, and evolution and yet the concept remains poorly …

Nutritional ecology and human health

D Raubenheimer, SJ Simpson - Annual review of nutrition, 2016 - annualreviews.org
In contrast to the spectacular advances in the first half of the twentieth century with
micronutrient-related diseases, human nutrition science has failed to stem the more recent …