Dual-specificity protein phosphatases comprise a protein phosphatase subfamily with
selectivity towards mitogen-activated protein (MAP) kinases, also named MKPs, or mitogen …

Reassessment of published observations in patients with multiple sclerosis (MS) suggests a
microglial malfunction due to inappropriate (over) activity of the mitogen-activated protein …

Engineered variants of recombinant adeno-associated viruses (rAAVs) are being developed
rapidly to meet the need for gene-therapy delivery vehicles with particular cell-type and …

Single-cell combinatorial indexing (sci) with transposase-based library construction
increases the throughput of single-cell genomics assays but produces sparse coverage in …

The integrated stress response (ISR) is an essential stress-support pathway increasingly
recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in …

Background At present, coronavirus disease 2019 (COVID-19), caused by infection with
severe acute respiratory syndrome coronavirus 2, is spreading all over the world, with …

Personalized treatment for patients with advanced solid tumors critically depends on the
deep characterization of tumor cells from patient biopsies. Here, we comprehensively …

Nasal‐type natural killer/T‐cell lymphoma (NKTCL) is an aggressive malignancy with poor
survival outcomes that is relatively resistant to chemotherapy. N6‐Methyladenosine (m6A) …

Despite significant advances in developing selective JAK2 inhibitors, JAK2 kinase inhibitor
(TKI) therapy is ineffective in suppressing the disease. Reactivation of compensatory MEK …

The clinical benefit of MAPK pathway inhibition in BRAF-mutant melanoma patients is
limited by the development of acquired resistance. Using drug-naïve cell lines derived from …