Simple Summary In this review, the authors propose a crosswise examination of cytarabine-
related issues ranging from the spectrum of clinical activity and severe toxicities, through …

The mainstay of acute myeloid leukemia chemotherapy is the nucleoside analog cytarabine
(ara-C). Numerous studies suggest that the intracellular concentrations of the ara-C active …

ATP-binding cassette (ABC) transporters confer drug resistance against a wide range of
chemotherapeutic agents, including nucleoside and nucleotide based drugs. While …

Gemcitabine is considered the standard first-line therapy for patients with advanced
pancreatic cancer. More recent strategies have focused on improving the efficacy of …

Cytarabine (ara-C) is the most effective agent for the treatment of acute myeloid leukaemia
(AML). Aberrant expression of enzymes involved in the transport/metabolism of ara-C could …

Cytotoxic deoxynucleoside analogues are widely used in the treatment of haematological
malignancies and solid tumours. Their metabolism and mechanisms of action are relatively …

Glioblastoma multiforme (GBM), the most frequent malignant brain tumor, has a poor
prognosis, but is relatively sensitive to radiation. Both gemcitabine and its metabolite …

Acute myelogenous leukemia (AML) is an extremely heterogeneous neoplasm with several
clinical, pathological, genetic and molecular subtypes. Combinations of various doses and …

Background L-Leucovorin (l-LV; 5-formyltetrahydrofolate, folinic acid) is a precursor for 5, 10-
methylenetetrahydrofolate (5, 10-CH2-THF), which is important for the potentiation of the …

Neutron capture therapy (NCT) is a binary radio-chemotherapeutic modality for the treatment
of cancer. A major focus of NCT-related research is the development of novel tumor …