The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients …

DNA-damaging agents are widely used in clinical oncology and exploit deficiencies in tumor
DNA repair. Given the expanding role of immune checkpoint blockade as a therapeutic …

Background Preclinical studies have found radiotherapy enhances antitumour immune
responses. We aimed to assess disease control and pulmonary toxicity in patients who …

Purpose Stereotactic body radiotherapy (SBRT) may stimulate innate and adaptive immunity
to augment immunotherapy response. Multisite SBRT is an emerging paradigm for treating …

The recent success of cancer immunotherapy has demonstrated the power of the immune
system to clear tumors, generating renewed enthusiasm for identifying ways to induce …

Approximately one‐half of patients with newly diagnosed cancer and many patients with
persistent or recurrent tumors receive radiotherapy (RT), with the explicit goal of eliminating …

The past 20 years have seen dramatic changes in the delivery of radiation therapy, but the
impact of radiobiology on the clinic has been far less substantial. A major consideration in …

Technological developments have allowed improvements in radiotherapy delivery, with
higher precision and better sparing of normal tissue. For many years, it has been well known …

T cells directed to endogenous tumor antigens are powerful mediators of tumor regression.
Recent immunotherapy advances have identified effective interventions to unleash tumor …

The therapeutic application of ionizing radiation has been largely based on its cytocidal
power combined with the ability to selectively target tumors. Radiotherapy effects on survival …