The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

Selected topics in the respiratory response to acute hypoxia in the fetus and newborn are
reviewed. Peripheral chemoreceptors acting through ionotrophic glutamate receptors play …

Obstructive sleep apnea (OSA) is an increasingly recognized, common chronic disease in
the developed nations and is a complex disease that has high social and economic costs …

Regulation of blood flow depends on systemic and local release of vasoactive molecules
such as insulin and adenosine. These molecules cause vasodilation by activation of plasma …

Objective: To characterize postnatal maturation of the biphasic ventilatory response to
hypoxia in order to determine whether it persists beyond the first weeks of life in preterm …

Background and aims: Necrotising enterocolitis (NEC) is a potentially devastating disorder
of preterm infants but its aetiology remains unclear. The aim of these studies was to develop …

The role of adenosine in the modulation of respiration-related neurons was examined using
an in vitro brainstem-spinal cord preparation from neonatal rats (0-4 d old). Respiratory …

The perinatal development of respiratory rhythm generation and its modulation by
adenosinergic drugs have been examined in rats from embryonic d 18 (E18) to postnatal d 3 …

Previously, we found heightened expression of inhibitory neurochemicals and depressed
expression of excitatory neurochemicals with a sudden drop in metabolic activity around …

Despite its vital importance to life, respiration is not mature at birth in mammals, but rather, it
undergoes a great deal of growth, refinement, and adjustments postnatally. Many …