CD4 T cells with cytotoxic function were once thought to be an artifact due to long-term in
vitro cultures but have in more recent years become accepted and reported in the literature …

Nucleic acids carry the building plans of living systems. As such, they can be exploited to
make cells produce a desired protein, or to shut down the expression of endogenous genes …

Early immunological events during acute HIV infection are thought to fundamentally
influence long-term disease outcome. Whereas the contribution of HIV-specific CD8 T cell …

CD4 T cells that acquire cytotoxic phenotype and function have been repeatedly identified in
humans, mice, and other species in response to many diverse pathogens. Since CD4 …

CD4+ T cells orchestrate adaptive immune responses through their capacity to recruit and
provide help to multiple immune effectors, in addition to exerting direct effector functions …

It is generally believed that the role of CD4+ T cells is to coordinate the different arms of the
adaptive immune system to shape an effective response against a pathogen and regulate …

Multiple epidemiological studies have demonstrated associations between the human
leukocyte antigen (HLA) loci and human immunodeficiency virus (HIV) disease, and more …

Live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) remain the most
efficacious of all vaccines in nonhuman primate models of HIV and AIDS, yet the basis of …

In a phase I/IIa clinical trial, 17 HIV-1 infected patients, stable on cART, received 4
vaccinations with autologous dendritic cells electroporated with mRNA encoding Tat, Rev …

CD4+ T cells play a central role in the immunopathogenesis of HIV/AIDS, and their depletion
during chronic HIV infection is a hallmark of disease progression. However, the relative …