Neurons, nose, and neurodegenerative diseases: olfactory function and cognitive impairment

I Fatuzzo, GF Niccolini, F Zoccali, L Cavalcanti… - International Journal of …, 2023 - mdpi.com
Olfactory capacity declines with aging, but increasing evidence shows that smell dysfunction
is one of the early signs of prodromal neurodegenerative diseases such as Alzheimer's and …

Olfactory dysfunction in the pathophysiological continuum of dementia

P Bathini, E Brai, LA Auber - Ageing research reviews, 2019 - Elsevier
Sensory capacities like smell, taste, hearing, vision decline with aging, but increasing
evidence show that sensory dysfunctions are one of the early signs diagnosing the …

Single-cell RNA-Seq analysis of olfactory mucosal cells of Alzheimer's disease patients

R Lampinen, MF Fazaludeen, S Avesani, T Örd… - Cells, 2022 - mdpi.com
Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity.
Olfactory dysfunction manifests early in several neurodegenerative disorders including …

Autologous olfactory mucosa mesenchymal stem cells treatment improves the neural network in chronic refractory epilepsy

ZZ Liu, Y Huang, CG Hong, X Wang, R Duan… - Stem Cell Research & …, 2023 - Springer
Background and aims Refractory epilepsy is also known as drug-resistant epilepsy with
limited clinical treatment. Benefitting from its safety and easy availability, olfactory mucosa …

[HTML][HTML] Olfactory identification in subjective cognitive decline and mild cognitive impairment: association with tau but not amyloid positron emission tomography

SL Risacher, EF Tallman, JD West, KK Yoder… - Alzheimer's & Dementia …, 2017 - Elsevier
Introduction We investigated the association between olfactory identification and Alzheimer's
disease biomarkers, including amyloid, tau, and neurodegeneration. Methods Thirty-four …

Unraveling the Link between Olfactory Deficits and Neuropsychiatric Disorders

K Yang, C Ayala-Grosso, JP Bhattarai… - Journal of …, 2023 - Soc Neuroscience
Smell loss has caught public attention during the recent COVID-19 pandemic. Research on
olfactory function in health and disease gains new momentum. Smell deficits have long …

[HTML][HTML] Smaller grey matter volume in the central olfactory system in mild cognitive impairment

B Jobin, B Boller, J Frasnelli, CQ The - Experimental Gerontology, 2023 - Elsevier
One of the major challenges in the diagnosis of Alzheimer's disease (AD) is to increase the
specificity of the early diagnosis. While episodic memory impairment is a sensitive AD …

Biomarkers in Alzheimer's Disease: Are Olfactory Neuronal Precursors Useful for Antemortem Biomarker Research?

V Santillán-Morales, N Rodriguez-Espinosa… - Brain Sciences, 2024 - mdpi.com
Alzheimer's disease (AD), as the main cause of dementia, affects millions of people around
the world, whose diagnosis is based mainly on clinical criteria. Unfortunately, the diagnosis …

Analyzing olfactory neuron precursors non-invasively isolated through NADH FLIM as a potential tool to study oxidative stress in Alzheimer's disease

L Gómez-Virgilio, A Luarte, DP Ponce… - International Journal of …, 2021 - mdpi.com
Among all the proposed pathogenic mechanisms to understand the etiology of Alzheimer's
disease (AD), increased oxidative stress seems to be a robust and early disease feature …

RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer's disease: genome-wide transcriptomic profiling and bioinformatics data mining

A Hadar, E Milanesi, A Squassina, P Niola… - Translational …, 2016 - nature.com
Alzheimer's disease (AD) is the most frequent cause of dementia. Misfolded protein
pathological hallmarks of AD are brain deposits of amyloid-β (Aβ) plaques and …