Uncovering the neurophysiology of mood, motivation and behavioral symptoms in Parkinson's disease through intracranial recordings

L Ricciardi, M Apps, S Little - npj Parkinson's Disease, 2023 - nature.com
Neuropsychiatric mood and motivation symptoms (depression, anxiety, apathy, impulse
control disorders) in Parkinson's disease (PD) are highly disabling, difficult to treat and …

Clinical neuroscience and neurotechnology: An amazing symbiosis

A Cometa, A Falasconi, M Biasizzo, J Carpaneto… - Iscience, 2022 - cell.com
In the last decades, clinical neuroscience found a novel ally in neurotechnologies, devices
able to record and stimulate electrical activity in the nervous system. These technologies …

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

Y Jiang, Z Qi, H Zhu, K Shen, R Liu… - Neural Regeneration …, 2025 - journals.lww.com
The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is
characterized by degeneration of dopamine-producing cells in the substantia nigra, which …

Pallidal neuromodulation of the explore/exploit trade-off in decision-making

AL de A Marcelino, O Gray, B Al-Fatly, W Gilmour… - Elife, 2023 - elifesciences.org
Every decision that we make involves a conflict between exploiting our current knowledge of
an action's value or exploring alternative courses of action that might lead to a better, or …

[HTML][HTML] Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A mendelian randomization study

Z Wang, S Wang, H Li, M Wang, X Zhang, J Xu, Q Xu… - Heliyon, 2024 - cell.com
A few observational neuroimaging investigations have reported subcortical structural
changes in the individuals who recovered from the coronavirus disease‐2019 (COVID‐19) …

Clinical management model for impulse control disorders in Parkinson's disease

H Li, Y Yang, L Yang, A Xie - CNS spectrums, 2024 - cambridge.org
Over the last decade, we have gained a better understanding of impulse control disorder in
Parkinson's disease (PD-ICD), a medication complication in PD. Researchers were aware of …

[HTML][HTML] More widespread and rigid neuronal representation of reward expectation underlies impulsive choices

RL Cowan, T Davis, B Kundu, S Rahimpour… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Impulsive choices prioritize smaller, more immediate rewards over larger, delayed, or
potentially uncertain rewards. Impulsive choices are a critical aspect of substance use …

[HTML][HTML] Pallidal neuromodulation of the explore/exploit trade-off in decision-making

M ALdA, O Gray, B Al-Fatly, W Gilmour, JD Steele… - 2022 - europepmc.org
Every decision that we make involves a conflict between exploiting our current knowledge of
an action's value or exploring alternative courses of action that might lead to a better, or …

[PDF][PDF] Effects of DBS-STN on Impulsivity and Other Psychiatric Symptoms in Parkinson's Disease

AA Ahmed - kclpure.kcl.ac.uk
Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1% of people
aged over sixty. Although PD is considered a movement disorder, psychiatric symptoms …