The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism
Pyruvate metabolism, a central nexus of carbon homeostasis, is an evolutionarily conserved
process and aberrant pyruvate metabolism is associated with and contributes to numerous …
process and aberrant pyruvate metabolism is associated with and contributes to numerous …
Fifty years of the mitochondrial pyruvate carrier: New insights into its structure, function, and inhibition
The mitochondrial pyruvate carrier (MPC) resides in the mitochondrial inner membrane,
where it links cytosolic and mitochondrial metabolism by transporting pyruvate produced in …
where it links cytosolic and mitochondrial metabolism by transporting pyruvate produced in …
Human mitochondrial carriers of the SLC25 family function as monomers exchanging substrates with a ping-pong kinetic mechanism
C Cimadamore-Werthein, MS King… - The EMBO …, 2024 - embopress.org
Members of the SLC25 mitochondrial carrier family link cytosolic and mitochondrial
metabolism and support cellular maintenance and growth by transporting compounds …
metabolism and support cellular maintenance and growth by transporting compounds …
The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma
S Findlay, R Nair, RA Merrill, Z Kaiser… - Blood …, 2023 - ashpublications.org
Multiple myeloma (MM) is a hematological malignancy that emerges from antibody-
producing plasma B cells. Proteasome inhibitors, including the US Food and Drug …
producing plasma B cells. Proteasome inhibitors, including the US Food and Drug …
The hepatic mitochondrial pyruvate carrier as a regulator of systemic metabolism and a therapeutic target for treating metabolic disease
KS McCommis, BN Finck - Biomolecules, 2023 - mdpi.com
Pyruvate sits at an important metabolic crossroads of intermediary metabolism. As a product
of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy …
of glycolysis in the cytosol, it must be transported into the mitochondrial matrix for the energy …
UK5099 Inhibits the NLRP3 Inflammasome Independently of its Long‐Established Target Mitochondrial Pyruvate Carrier
L Ran, M Chen, J Ye, S Zhang, Z Luo, T Bai… - Advanced …, 2024 - Wiley Online Library
Targeting NLRP3 inflammasome has been recognized as a promising therapeutic strategy
for the treatment of numerous common diseases. UK5099, a long‐established inhibitor of …
for the treatment of numerous common diseases. UK5099, a long‐established inhibitor of …
Glucose-1, 6-bisphosphate: A new gatekeeper of cerebral mitochondrial pyruvate uptake
MS Safari, P Woerl, C Garmsiri, D Weber… - Molecular …, 2024 - Elsevier
Abstract Objective Glucose-1, 6-bisphosphate (G-1, 6-BP), a byproduct of glycolysis that is
synthesized by phosphoglucomutase 2 like 1 (PGM2L1), is particularly abundant in neurons …
synthesized by phosphoglucomutase 2 like 1 (PGM2L1), is particularly abundant in neurons …
A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite Blastocystis
Stramenopiles form a clade of diverse eukaryotic organisms, including multicellular algae,
the fish and plant pathogenic oomycetes, such as the potato blight Phytophthora, and the …
the fish and plant pathogenic oomycetes, such as the potato blight Phytophthora, and the …
[HTML][HTML] The free-living flagellate Paratrimastix pyriformis uses a distinct mitochondrial carrier to balance adenine nucleotide pools
J Zítek, MS King, P Peña-Diaz, E Pyrihová… - Archives of Biochemistry …, 2023 - Elsevier
Paratrimastix pyriformis is a free-living flagellate thriving in low-oxygen freshwater
sediments. It belongs to the group Metamonada along with human parasites, such as …
sediments. It belongs to the group Metamonada along with human parasites, such as …
Design, synthesis and biological evaluation of novel cyano-cinnamate derivatives as mitochondrial pyruvate carrier inhibitors
Y Huang, X Peng, H Zhang, M Pan, X Su, G Li… - Bioorganic & Medicinal …, 2024 - Elsevier
Mitochondrial pyruvate carrier (MPC) inhibitors promote the development of hair follicle stem
cells without affecting normal cells, which is promising for the treatment of hair loss. Herein …
cells without affecting normal cells, which is promising for the treatment of hair loss. Herein …