Viruses are fully reliant on the translation machinery of their host cells to produce the
polypeptides that are essential for viral replication. Consequently, viruses recruit host …

▪ Abstract Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates
recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under …

The multisubunit eukaryotic translation initiation factor (eIF) 4F recruits 40S ribosomal
subunits to the 5′ end of mRNA. The eIF4F subunit eIF4E interacts directly with the mRNA …

The proper functioning of the pathways that are involved in the sensing and management of
nutrients is central to metabolic homeostasis and is therefore among the most fundamental …

In most instances, translation is regulated at the initiation phase, when a ribosome is
recruited to the 5′ end of an mRNA. The eIF4E-binding proteins (4E-BPs) interdict …

Initiation of translation of most eukaryotic mRNAs commences with 5 end–dependent
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

Growth factors and hormones activate protein translation by phosphorylation and
inactivation of the translational repressors, the eIF4E-binding proteins (4E-BPs), through a …

Human eukaryotic translation initiation factor 4E (eIF4E) binds to the mRNA cap structure
and interacts with eIF4G, which serves as a scaffold protein for the assembly of eIF4E and …

As obligate intracellular parasites, virus reproduction requires host cell functions. Despite
variations in genome size and configuration, nucleic acid composition, and their repertoire of …