ARF GTPases and their GEFs and GAPs: concepts and challenges
E Sztul, PW Chen, JE Casanova… - Molecular biology of …, 2019 - Am Soc Cell Biol
Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …
required to develop models of its actions in cells. Studying a protein family in the aggregate …
Macropinocytosis: mechanisms and regulation
G Salloum, AR Bresnick, JM Backer - Biochemical Journal, 2023 - portlandpress.com
Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …
Insights into immune responses in oral cancer through proteomic analysis of saliva and salivary extracellular vesicles
FV Winck, AC Prado Ribeiro, R Ramos Domingues… - Scientific reports, 2015 - nature.com
The development and progression of oral cavity squamous cell carcinoma (OSCC) involves
complex cellular mechanisms that contribute to the low five-year survival rate of …
complex cellular mechanisms that contribute to the low five-year survival rate of …
The role of ARF family proteins and their regulators and effectors in cancer progression: a therapeutic perspective
The Adenosine diphosphate-Ribosylation Factor (ARF) family belongs to the RAS
superfamily of small GTPases and is involved in a wide variety of physiological processes …
superfamily of small GTPases and is involved in a wide variety of physiological processes …
ARL13B regulates Sonic hedgehog signaling from outside primary cilia
ED Gigante, MR Taylor, AA Ivanova, RA Kahn… - Elife, 2020 - elifesciences.org
ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts
cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether …
cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether …
Primary cilia proteins: ciliary and extraciliary sites and functions
K Hua, RJ Ferland - Cellular and Molecular Life Sciences, 2018 - Springer
Primary cilia are immotile organelles known for their roles in development and cell signaling.
Defects in primary cilia result in a range of disorders named ciliopathies. Because this …
Defects in primary cilia result in a range of disorders named ciliopathies. Because this …
Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules
Tubulin polyglutamylation is a predominant axonemal post-translational modification.
However, if and how axoneme polyglutamylation is essential for primary cilia and contribute …
However, if and how axoneme polyglutamylation is essential for primary cilia and contribute …
Arf proteins in cancer cell migration
Members of the ADP-ribosylation factor (Arf) family of small GTP-binding (G) proteins
regulate several aspects of membrane trafficking, such as vesicle budding, tethering and …
regulate several aspects of membrane trafficking, such as vesicle budding, tethering and …
Actin dynamics regulates dendritic cell-mediated transfer of HIV-1 to T cells
MM Ménager, DR Littman - Cell, 2016 - cell.com
Whereas human dendritic cells (DCs) are largely resistant to productive infection with HIV-1,
they have a unique ability to take up the virus and transmit it efficiently to T lymphocytes …
they have a unique ability to take up the virus and transmit it efficiently to T lymphocytes …
Arl13b and the exocyst interact synergistically in ciliogenesis
C Seixas, SY Choi, N Polgar… - Molecular biology of …, 2016 - Am Soc Cell Biol
Arl13b belongs to the ADP-ribosylation factor family within the Ras superfamily of regulatory
GTPases. Mutations in Arl13b cause Joubert syndrome, which is characterized by …
GTPases. Mutations in Arl13b cause Joubert syndrome, which is characterized by …