The formation of reactive oxygen species (ROS) by the myeloid cell NADPH oxidase NOX2
is critical for the destruction of engulfed microorganisms. However, recent studies imply that …

The diverse repertoires of cellular mechanisms that progress certain cancer types are being
uncovered by recent research and leading to more effective treatment options. Ovarian …

The NADPH-dependent oxidase NOX2 is an important effector of immune cell function, and
its activity has been linked to oncogenic signaling. Here, we describe a role for NOX2 in …

Reactive oxygen species (ROS), previously considered toxic by-products of aerobic
metabolism, are increasingly recognized as regulators of cellular signaling. Keeping ROS …

Significance: The primary function of NADPH oxidases (NOX1–5 and dual oxidases
DUOX1/2) is to produce reactive oxygen species (ROS). If inadequately regulated, NOX …

Activation of NADPH oxidases (NOX) and the ensuing formation of reactive oxygen species
(ROS) is a vital aspect of antimicrobial defense but may also promote tumorigenesis …

Mutations leading to constitutive RAS activation contribute in myeloid leukemogenesis. RAS
mutations in myeloid cells are accompanied by excessive formation of reactive oxygen …

In acute myeloid leukemia (AML), a low level of reactive oxygen species (ROS) is associated
with leukemic stem cell (LSC) quiescence, whereas a high level promotes blast proliferation …

In patients with acute myeloid leukemia (AML), treatment with histamine dihydrochloride
(HDC) and low-dose IL-2 (HDC/IL-2) in the post-chemotherapy phase has been shown to …

[ES] La leucemia mieloide aguda (LMA) es la leucemia más diagnosticada en adultos. Su
abordaje clínico es complejo debido, principalmente, a su gran heterogeneidad. Esto ha …