New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Genome mining methods to discover bioactive natural products

KD Bauman, KS Butler, BS Moore… - Natural Product …, 2021 - pubs.rsc.org
Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Structure of the bacterial ribosome at 2 Å resolution

ZL Watson, FR Ward, R Méheust, O Ad, A Schepartz… - elife, 2020 - elifesciences.org
Using cryo-electron microscopy (cryo-EM), we determined the structure of the Escherichia
coli 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous …

Spectroscopic characterization (IR, UV-Vis), and HOMO-LUMO, MEP, NLO, NBO analysis and the antifungal activity for 4-bromo-N-(2-nitrophenyl) benzamide; using …

SK Alghamdi, F Abbas, RK Hussein… - Journal of Molecular …, 2023 - Elsevier
In this study, the density functional theory was used to explore the spectral and electronic
properties of the title molecule, as well as a molecular docking technique to evaluate its …

Decoding directing groups and their pivotal role in C− H activation

K Murali, LA Machado, RL Carvalho… - … A European Journal, 2021 - Wiley Online Library
Synthetic organic chemistry has witnessed a plethora of functionalization and
defunctionalization strategies. In this regard, C− H functionalization has been at the forefront …

Ynamide coupling reagents: origin and advances

L Hu, J Zhao - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus Since the pioneering work of Curtius and Fischer, chemical peptide synthesis
has witnessed a century's development and evolved into a routine technology. However, it is …

Site-selective modification of peptide backbones

A Boto, CC González, D Hernández… - Organic Chemistry …, 2021 - pubs.rsc.org
The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

Construction of hybrid ionic liquid‐catalysts for the highly effective conversion of H2S by nitriles into thioamides

W Xiong, S Wen, X Zhang, X Hu, Y Wu - AIChE Journal, 2024 - Wiley Online Library
Described herein presents a kind of multisite hybrid ionic liquid‐catalysts and establishes a
novel strategy for H2S utilization, which has been characterized by multiaspects to reveal …

Thioamide Analogues of MHC I Antigen Peptides

R Gibadullin, RK Morris, J Niu, J Sidney… - Journal of the …, 2023 - ACS Publications
Short, synthetic peptides that are displayed by major histocompatibility complex I (MHC I)
can stimulate CD8 T cells in vivo to destroy virus-infected or cancer cells. The development …

The many facets of sulfur incorporation in natural product biosynthesis

AD Steele, AF Kiefer, B Shen - Current Opinion in Chemical Biology, 2023 - Elsevier
Sulfur-containing natural products (S-containing NPs) exhibit diverse chemical structures
and biosynthetic machineries. Unraveling the intricate chemistry of S-incorporation requires …