Mutations in DOCK8 result in autosomal recessive Hyper-IgE syndrome with combined
immunodeficiency (CID). However, the natural course of disease, long-term prognosis, and …

Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

Background Mutations in dedicator of cytokinesis 8 (DOCK8) cause a combined
immunodeficiency (CID) also classified as autosomal recessive (AR) hyper-IgE syndrome …

Background Recurrent bacterial and fungal infections, eczema, and increased serum IgE
levels characterize patients with the hyper-IgE syndrome (HIES). Known genetic causes for …

The hyper-IgE syndromes (HIES; originally named Job's syndrome) are a collection of
primary immunodeficiency syndromes resulting in elevated serum IgE levels and typified by …

Background Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX)
syndrome is a rare inborn error of immunity caused by mutations in the forkhead box P3 …

Background Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
caused by autosomal recessive loss-of-function mutations in DOCK8. This disorder is …

Background Dedicator of cytokinesis 8 (DOCK8) deficiency is typified by recurrent infections,
increased serum IgE levels, eosinophilia, and a high incidence of allergic and autoimmune …

IgE is a type of antibody linked with host defense against parasitic infection. However, in
most countries with a low incidence of parasitic infection, high IgE is more commonly …