Adipose tissue dysfunction as determinant of obesity-associated metabolic complications
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …
Adipogenesis as a potential anti-obesity target: A review of pharmacological treatment and natural products
Obesity is recognized as a severe threat to overall human health and is associated with type
2 diabetes mellitus, dyslipidemia, hypertension, and cardiovascular diseases. Abnormal …
2 diabetes mellitus, dyslipidemia, hypertension, and cardiovascular diseases. Abnormal …
Mechanisms mediating the regulation of peroxisomal fatty acid beta-oxidation by PPARα
M Tahri-Joutey, P Andreoletti, S Surapureddi… - International journal of …, 2021 - mdpi.com
In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …
Therapeutic potential of vital transcription factors in Alzheimer's and Parkinson's disease with particular emphasis on transcription factor EB mediated autophagy
Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …
PPARs as nuclear receptors for nutrient and energy metabolism
F Hong, S Pan, Y Guo, P Xu, Y Zhai - Molecules, 2019 - mdpi.com
It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs)
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …
PPARs-orchestrated metabolic homeostasis in the adipose tissue
C Sun, S Mao, S Chen, W Zhang, C Liu - International journal of …, 2021 - mdpi.com
It has been more than three decades since peroxisome proliferator-activated receptors
(PPARs) were first discovered. Many investigations have revealed the central regulators of …
(PPARs) were first discovered. Many investigations have revealed the central regulators of …
Linking obesity with colorectal cancer: epidemiology and mechanistic insights
The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades.
More than 650 million obese and 2 billion overweight individuals are currently living in the …
More than 650 million obese and 2 billion overweight individuals are currently living in the …
[HTML][HTML] Advances in multi-omics study of biomarkers of glycolipid metabolism disorder
X Fang, R Miao, J Wei, H Wu, J Tian - Computational and Structural …, 2022 - Elsevier
Glycolipid metabolism disorder are major threats to human health and life. Genetic,
environmental, psychological, cellular, and molecular factors contribute to their …
environmental, psychological, cellular, and molecular factors contribute to their …
Deregulated transcription factors in cancer cell metabolisms and reprogramming
Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer
malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to …
malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to …
[HTML][HTML] Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: A prospective …
G Yu, M Jin, Y Huang, R Aimuzi, T Zheng, M Nian… - Environment …, 2021 - Elsevier
Background Humans are widely exposed to environmental perfluoroalkyl substances
(PFAS), which may affect glucose homeostasis. However, research linking PFAS exposure …
(PFAS), which may affect glucose homeostasis. However, research linking PFAS exposure …