Stored maternal factors in oocytes regulate oocyte differentiation into embryos during early
embryonic development. Before zygotic gene activation (ZGA), these early embryos are …

We present two cases of infertile males with teratozoospermia stemming from chromosome
17 translocation. The patients present karyotypes that have not been previously reported …

Oocytes become enclosed in primordial follicles during fetal life and remain dormant there
until activation followed by growth and meiotic resumption. Current knowledge about the …

Abstract Intraflagellar transport protein 20 (IFT20) is essential for spermatogenesis in mice.
We discovered that COPS5 was a major binding partner of IFT20. COPS5 is the fifth …

Colorectal cancer (CRC) is one of the most aggressive cancers with poor prognosis and
high mortality. The study of the pathogenesis of CRC is a top priority in providing effective …

Investigations of genes required in early mammalian development are complicated by
protein deposits of maternal products, which continue to operate after the gene locus has …

Background: The COP9 signalosome (CSN) consisting of 8 unique protein subunits (COPS1
through COPS8) serves as the cullin deneddylase, regulating the catalytic dynamics of cullin …

Disorders of vascular function contribute importantly to cardiovascular disease which
represents a substantial cause of morbidity and mortality worldwide. An emerging paradigm …

Abstract Background The SMC5/6 complex, cohesin and condensin are the three
mammalian members of the structural maintenance of chromosomes (SMC) family, large …

Premature ovarian failure (POF) is defined as loss of ovarian function in women less than 40
years of age. The causes of POF are diverse and include environmental factors. Di-2 …