Parkinson's disease: etiopathogenesis and treatment

J Jankovic, EK Tan - Journal of Neurology, Neurosurgery & Psychiatry, 2020 - jnnp.bmj.com
The concept of 'idiopathic'Parkinson's disease (PD) as a single entity has been challenged
with the identification of several clinical subtypes, pathogenic genes and putative causative …

Hallmarks of brain aging: adaptive and pathological modification by metabolic states

MP Mattson, TV Arumugam - Cell metabolism, 2018 - cell.com
During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

The pharmacological action of kaempferol in central nervous system diseases: a review

J Silva dos Santos, JP Goncalves Cirino… - Frontiers in …, 2021 - frontiersin.org
Kaempferol (KPF) is a flavonoid antioxidant found in fruits and vegetables. Many studies
have described the beneficial effects of dietary KPF in reducing the risk of chronic diseases …

A quarter century of APOE and Alzheimer's disease: progress to date and the path forward

ME Belloy, V Napolioni, MD Greicius - Neuron, 2019 - cell.com
Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

Bee venom: Overview of main compounds and bioactivities for therapeutic interests

R Wehbe, J Frangieh, M Rima, D El Obeid, JM Sabatier… - Molecules, 2019 - mdpi.com
Apitherapy is an alternate therapy that relies on the usage of honeybee products, most
importantly bee venom for the treatment of many human diseases. The venom can be …

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

N Allocati, M Masulli, C Di Ilio, L Federici - Oncogenesis, 2018 - nature.com
Glutathione transferase classical GSH conjugation activity plays a critical role in cellular
detoxification against xenobiotics and noxious compounds as well as against oxidative …

The neuropathological diagnosis of Alzheimer's disease

MA DeTure, DW Dickson - Molecular neurodegeneration, 2019 - Springer
Alzheimer's disease is a progressive neurodegenerative disease most often associated with
memory deficits and cognitive decline, although less common clinical presentations are …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?

KA Jellinger, AD Korczyn - BMC medicine, 2018 - Springer
Abstract Background Dementia with Lewy bodies (DLB) and Parkinson's disease dementia
(PDD), which share many clinical, neurochemical, and morphological features, have been …

Dynamic functional connectivity changes associated with dementia in Parkinson's disease

E Fiorenzato, AP Strafella, J Kim, R Schifano, L Weis… - Brain, 2019 - academic.oup.com
Dynamic functional connectivity captures temporal variations of functional connectivity
during MRI acquisition and it may be a suitable method to detect cognitive changes in …